Cruzain-IN-1

• 常用名: Cruzain-IN-1
• 英文名: Cruzain-IN-1
• CAS号: 1199523-24-4
• 分子量: 300.26600
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₁₀F₂N₆
• 熔点: N/A
• 闪点: N/A

Cruzain-IN-1用途

Cruzain-IN-1 是克鲁斯氏锥体虫半胱氨酸蛋白酶 (Cruzain) 的共价可逆抑制剂,其 IC50 值为 10 nM。

Cruzain-IN-1名称

• 中文名: Cruzain-IN-1
• 英文名: 6-(3,6-difluorophenylamino)-9-ethyl-9H-purine-2-carbonitrile

Cruzain-IN-1生物活性

• 描述: Cruzain-IN-1 是克鲁斯氏锥体虫半胱氨酸蛋白酶 (Cruzain) 的共价可逆抑制剂,其 IC50 值为 10 nM。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 其他
• 靶点实验:

  IC50:10 nM (Cruzain)[1].

• 参考文献:

  [1]. Lee GM, et al. Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy. Biochemistry. 2012 Dec 18;51(50):10087-98.

Cruzain-IN-1物理化学性质

• 分子式: C₁₄H₁₀F₂N₆
• 分子量: 300.26600
• 精确质量: 300.09400
• PSA: 79.42000
• LogP: 2.81268
• InChIKey: SZYYBVWPURUFRR-UHFFFAOYSA-N
• SMILES: CCn1cnc2c(Nc3cc(F)cc(F)c3)nc(C#N)nc21
• 储存条件: 2-8℃

Cruzain-IN-1靶点实验

查看更多实验

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

实验名称：Antitrypanosomal activity against Trypanosoma cruzi Y trypomastigotes infected in mou... 来源：ChEMBL 靶标：Trypanosoma cruzi External Id：CHEMBL1040847

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

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