N-[5-(6-chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide

• 常用名: N-[5-(6-chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide
• 英文名: N-[5-(6-chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide
• CAS号: 1202550-93-3
• 分子量: 388.9
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₇ClN₄O₂S
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-[5-(6-chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide

物理化学性质

• 分子式: C₁₈H₁₇ClN₄O₂S
• 分子量: 388.9
• InChIKey: UNQXIRZDOXDTMH-UHFFFAOYSA-N
• SMILES: CCS(=O)(=O)NCc1cncc(-c2c(C#N)c3ccc(Cl)cc3n2C)c1

靶点实验

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实验名称：Inhibition of CYP11B2 in human H285R cells assessed as decrease in [125I] angiotensin... 来源：ChEMBL 靶标：Cytochrome P450 11B2, mitochondrial External Id：CHEMBL3750668

实验名称：Half life in rat liver microsomes after 30 mins by LC/MS/MS analysis 来源：ChEMBL 靶标：Liver microsome External Id：CHEMBL3750672

实验名称：Inhibition of human CYP19 at 10 uM preincubated for 10 mins with NADPH followed by pr... 来源：ChEMBL 靶标：Aromatase External Id：CHEMBL3750671

实验名称：Selectivity ratio of IC50 for human recombinant CYP11B1 to IC50 for human recombinant... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3750670

实验名称：Inhibition of human recombinant CYP11B2 using 11-deoxycorticosterone as substrate aft... 来源：ChEMBL 靶标：Cytochrome P450 11B2, mitochondrial External Id：CHEMBL3750669

实验名称：Oral bioavailability in continuous angiotensin 2 infusion Sprague-Dawley rat model at... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3750676

实验名称：Clearance in continuous angiotensin-2 infusion Sprague-Dawley rat model at 3 mg/kg, p... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3750675

实验名称：Half life in human liver microsomes after 30 mins by LC/MS/MS analysis 来源：ChEMBL 靶标：Liver microsome External Id：CHEMBL3750673

实验名称：Toxicity in human assessed as increase in urinary 11-deoxycortisol level at 30 to 200... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL3750855

实验名称：Toxicity in human assessed as decrease in urinary cortisol level at 30 to 200 mg/kg, ... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL3750854

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