N-[2-(Dimethylamino)ethyl]-4-[({4-[4-morpholin-4-yl-7-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]phenyl}carbamoyl)amino]benzamide

• 常用名: N-[2-(Dimethylamino)ethyl]-4-[({4-[4-morpholin-4-yl-7-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]phenyl}carbamoyl)amino]benzamide
• 英文名: N-[2-(Dimethylamino)ethyl]-4-[({4-[4-morpholin-4-yl-7-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]phenyl}carbamoyl)amino]benzamide
• CAS号: 1202884-95-4
• 分子量: 610.6
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₀H₃₃F₃N₈O₃
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-[2-(Dimethylamino)ethyl]-4-[({4-[4-morpholin-4-yl-7-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]phenyl}carbamoyl)amino]benzamide

物理化学性质

• 分子式: C₃₀H₃₃F₃N₈O₃
• 分子量: 610.6
• InChIKey: ABOUWUWXUJHANF-UHFFFAOYSA-N
• SMILES: CN(C)CCNC(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)c4ccn(CC(F)(F)F)c4n3)cc2)cc1

靶点实验

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实验名称：Inhibition of human PI3Kalpha by fluorescence polarization format assay 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform External Id：CHEMBL1106090

实验名称：Cytotoxicity against human MDA-MB-361 cells with Her2+/PI3KCA mutant after 72 hrs 来源：ChEMBL 靶标：MDA-MB-361 External Id：CHEMBL1106099

实验名称：Solubility at pH 3 来源：ChEMBL 靶标：N/A External Id：CHEMBL1106098

实验名称：Half life in human liver microsomes 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL1106097

实验名称：Half life in rat liver microsomes 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL1106095

实验名称：Solubility at pH 7.4 来源：ChEMBL 靶标：N/A External Id：CHEMBL1106093

实验名称：Cytotoxicity against human PC3 cells with PTEN mutant after 72 hrs 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL1106092

实验名称：Inhibition of mTOR by DELFIA 来源：ChEMBL 靶标：Serine/threonine-protein kinase mTOR External Id：CHEMBL1106091

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