5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide

• 常用名: 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide
• 英文名: 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide
• CAS号: 1204519-52-7
• 分子量: 346.4
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₅H₁₈N₆O₂S
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide

物理化学性质

• 分子式: C₁₅H₁₈N₆O₂S
• 分子量: 346.4
• InChIKey: IVYWKCAOPCHVMX-UHFFFAOYSA-N
• SMILES: CC(C)(C)NS(=O)(=O)c1cncc(-c2ccn3nc(N)nc3c2)c1

靶点实验

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实验名称：Oral bioavailability in rat liver microsomes at 5 mg/kg; 1 mg/kg, iv 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL2216333

实验名称：Intrinsic clearance in rat liver microsomes 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL2216331

实验名称：Half life in rat liver microsomes at 5 mg/kg, po; 1 mg/kg, iv 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL2216337

实验名称：Volume of distribution at steady state in rat liver microsomes at 5 mg/kg, po; 1 mg/k... 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL2216335

实验名称：Inhibition of PI3Kbeta assessed as change in pIC50 by kinobeads assay 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform External Id：CHEMBL2215895

实验名称：Inhibition of PI3Kdelta assessed as change in pIC50 by kinobeads assay 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform External Id：CHEMBL2215896

实验名称：Inhibition of PI3Kgamma by kinobeads assay 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform External Id：CHEMBL2215893

实验名称：Inhibition of PI3Kalpha assessed as change in pIC50 by kinobeads assay 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform External Id：CHEMBL2215894

实验名称：Inhibition of PI3Kgamma/delta by neutrophil migration assay 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform External Id：CHEMBL2215897

实验名称：Inhibition of CYP2C19 at >20 uM 来源：ChEMBL 靶标：Cytochrome P450 2C19 External Id：CHEMBL2216349

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