(S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-b]pyrazin-5-yl)pyridin-3-yloxy)-3-(1H-indol-3-yl)propan-2-amine

• 常用名: (S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-b]pyrazin-5-yl)pyridin-3-yloxy)-3-(1H-indol-3-yl)propan-2-amine
• 英文名: (S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-b]pyrazin-5-yl)pyridin-3-yloxy)-3-(1H-indol-3-yl)propan-2-amine
• CAS号: 1208863-76-6
• 分子量: 465.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₃N₇O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: (S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-b]pyrazin-5-yl)pyridin-3-yloxy)-3-(1H-indol-3-yl)propan-2-amine

物理化学性质

• 分子式: C₂₆H₂₃N₇O₂
• 分子量: 465.5
• InChIKey: FULBTJANHDAKTA-SFHVURJKSA-N
• SMILES: Cc1[nH]nc2ncc(-c3cc(OCC(N)Cc4c[nH]c5ccccc45)cnc3-c3ccoc3)nc12

靶点实验

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实验名称：Inhibition of GSK3-beta phosphorylation in human BT474 cell xenografted SCID mouse at... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1071337

实验名称：Dose normalized AUC (0 to t) in mouse at 9.6 mg, ip 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1071991

实验名称：Drug level in tumor of human BT474 cells xenografted in SCID mouse at 50 mg/kg, ip 来源：ChEMBL 靶标：N/A External Id：CHEMBL1071338

实验名称：Inhibition of GSK3-beta phosphorylation in human BT474 cell xenografted SCID mouse at... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1071335

实验名称：Inhibition of GSK3-beta phosphorylation in human BT474 cell xenografted SCID mouse at... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1071336

实验名称：Selectivity ratio, IC50 for AKT to IC50 for PKA 来源：ChEMBL 靶标：N/A External Id：CHEMBL1071333

实验名称：Selectivity ratio, IC50 for AKT to IC50 for MSK1 来源：ChEMBL 靶标：N/A External Id：CHEMBL1071334

实验名称：Dose normalized AUC (0 to t) in dog at 2.4 mg, iv 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL1071998

实验名称：Clearance in dog at 2.4 mg, iv 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL1071999

实验名称：Dose normalized AUC (0 to t) in rat at 10.6 mg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1071994

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