6-(2,6-Difluorophenyl)-5-fluoro-n-(4-((1r,3s,5s)-3-hydroxy-5-methylcyclohexyl)pyridin-3-yl)picolinamide

• 常用名: 6-(2,6-Difluorophenyl)-5-fluoro-n-(4-((1r,3s,5s)-3-hydroxy-5-methylcyclohexyl)pyridin-3-yl)picolinamide
• 英文名: 6-(2,6-Difluorophenyl)-5-fluoro-n-(4-((1r,3s,5s)-3-hydroxy-5-methylcyclohexyl)pyridin-3-yl)picolinamide
• CAS号: 1210415-53-4
• 分子量: 441.4
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₂F₃N₃O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 6-(2,6-Difluorophenyl)-5-fluoro-n-(4-((1r,3s,5s)-3-hydroxy-5-methylcyclohexyl)pyridin-3-yl)picolinamide

物理化学性质

• 分子式: C₂₄H₂₂F₃N₃O₂
• 分子量: 441.4
• InChIKey: WUOBKQMEZQEJEO-ZNMIVQPWSA-N
• SMILES: CC1CC(O)CC(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C1

靶点实验

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实验名称：Hepatic extraction ratio in rat liver microsomes at 1 uM incubated for 30 mins in pre... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4723890

实验名称：Hepatic extraction ratio in human liver microsomes at 1 uM incubated for 30 mins in p... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4723891

实验名称：Intrinsic clearance in rat liver microsomes at 1 uM incubated for 30 mins in presence... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4723888

实验名称：Intrinsic clearance in human liver microsomes at 1 uM incubated for 30 mins in presen... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4723889

实验名称：ATP Depletion Assay from US Patent US8592455: "Kinase inhibitors and methods of their... 来源：BindingDB 靶标：N/A External Id：BindingDB_6059_1

实验名称：Apparent permeability from apical to basolateral side in human Caco2 cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL4723892

实验名称：Efflux ratio of apparent permeability across basolateral to apical side over apical t... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4723893

实验名称：Inhibition of PIM1 (unknown origin) using Bad peptide NH2-AGAGRSRHSSYPAGT-OH as subst... 来源：ChEMBL 靶标：Serine/threonine-protein kinase pim-1 External Id：CHEMBL4723883

实验名称：Antiproliferative activity against human KMS-11 cells expressing firefly luciferase a... 来源：ChEMBL 靶标：KMS-11 External Id：CHEMBL4723886

实验名称：Lipophilicity, log D of the compound at pH 7.4 来源：ChEMBL 靶标：N/A External Id：CHEMBL4723887

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