N-[4-(1H-Imidazol-1-ylmethyl)phenyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide

• 常用名: N-[4-(1H-Imidazol-1-ylmethyl)phenyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
• 英文名: N-[4-(1H-Imidazol-1-ylmethyl)phenyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
• CAS号: 1214429-43-2
• 分子量: 397.4
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₅N₅O₄S
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-[4-(1H-Imidazol-1-ylmethyl)phenyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide

物理化学性质

• 分子式: C₁₈H₁₅N₅O₄S
• 分子量: 397.4
• InChIKey: YUMCTBMIGMUWDS-UHFFFAOYSA-N
• SMILES: O=c1[nH]c(=O)c2cc(S(=O)(=O)Nc3ccc(Cn4ccnc4)cc3)ccc2[nH]1

靶点实验

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实验名称：Inhibition of human recombinant SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-... 来源：ChEMBL 靶标：NAD-dependent protein deacylase sirtuin-6 External Id：CHEMBL3625954

实验名称：Inhibition of human SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a sub... 来源：ChEMBL 靶标：NAD-dependent protein deacylase sirtuin-6 External Id：CHEMBL3625953

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实验名称：Inhibition of SIRT6 in human BxPC-3 cells assessed as increase in H3K9 acetylation by... 来源：ChEMBL 靶标：NAD-dependent protein deacylase sirtuin-6 External Id：CHEMBL3625951

实验名称：Selectivity ratio of IC50 for human SIRT2 to IC50 for human SIRT6 来源：ChEMBL 靶标：N/A External Id：CHEMBL3625958

实验名称：Selectivity ratio of IC50 for human SIRT1 to IC50 for human SIRT6 来源：ChEMBL 靶标：N/A External Id：CHEMBL3625957

实验名称：Inhibition of SIRT6 in rat L6 cells assessed as increase in radiolabelled glucose upt... 来源：ChEMBL 靶标：protein acetyllysine N-acetyltransferase External Id：CHEMBL3625962

实验名称：Inhibition of SIRT6 in human BxPC-3 cells assessed as increase in radiolabelled gluco... 来源：ChEMBL 靶标：NAD-dependent protein deacylase sirtuin-6 External Id：CHEMBL3625961

实验名称：Inhibition of SIRT6 in human PBMC assessed as inhibition of PHA-induced TNF alpha pro... 来源：ChEMBL 靶标：NAD-dependent protein deacylase sirtuin-6 External Id：CHEMBL3625965

实验名称：Inhibition of SIRT6 in rat L6 cells assessed as increase in 2-NBDG uptake at 100 uM a... 来源：ChEMBL 靶标：protein acetyllysine N-acetyltransferase External Id：CHEMBL3625963

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