2-N-((1S)-1-(5-Fluoropyrimidin-2-yl)ethyl)-4-N-(1-methylimidazol-4-yl)-7H-pyrrolo(2,3-d)pyrimidine-2,4-diamine

• 常用名: 2-N-((1S)-1-(5-Fluoropyrimidin-2-yl)ethyl)-4-N-(1-methylimidazol-4-yl)-7H-pyrrolo(2,3-d)pyrimidine-2,4-diamine
• 英文名: 2-N-((1S)-1-(5-Fluoropyrimidin-2-yl)ethyl)-4-N-(1-methylimidazol-4-yl)-7H-pyrrolo(2,3-d)pyrimidine-2,4-diamine
• CAS号: 1220516-48-2
• 分子量: 353.36
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₆FN₉
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 2-N-((1S)-1-(5-Fluoropyrimidin-2-yl)ethyl)-4-N-(1-methylimidazol-4-yl)-7H-pyrrolo(2,3-d)pyrimidine-2,4-diamine

物理化学性质

• 分子式: C₁₆H₁₆FN₉
• 分子量: 353.36
• InChIKey: QHXBWJSQXSYAGG-VIFPVBQESA-N
• SMILES: CC(Nc1nc(Nc2cn(C)cn2)c2cc[nH]c2n1)c1ncc(F)cn1

靶点实验

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实验名称：Human Janus kinase 3 (Janus kinase (JakA) family) 来源：IUPHAR-DB 靶标：Janus kinase 3 (Janus kinase (JakA) family) [Homo sapiens] External Id：2049_Human

实验名称：Human Janus kinase 1 (Janus kinase (JakA) family) 来源：IUPHAR-DB 靶标：Janus kinase 1 (Janus kinase (JakA) family) [Homo sapiens] External Id：2047_Human

实验名称：Half life in beagle dog at 2.5 mg/kg, iv 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL3118228

实验名称：Half life in beagle dog at 10 mg/kg, po 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL3118229

实验名称：Volume of distribution at steady state in beagle dog at 2.5 mg/kg, iv 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL3118230

实验名称：Clearance in beagle dog at 2.5 mg/kg, iv 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL3118231

实验名称：AUC (0 to 12 hrs) in beagle dog at 10 mg/kg, po 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL3118232

实验名称：Selectivity ratio of IC50 for human FGFR1 to IC50 for human JAK2 来源：ChEMBL 靶标：N/A External Id：CHEMBL3117021

实验名称：Selectivity ratio of IC50 for human ALK to IC50 for human JAK2 来源：ChEMBL 靶标：N/A External Id：CHEMBL3117022

实验名称：Selectivity ratio of IC50 for human Ret to IC50 for human JAK2 来源：ChEMBL 靶标：N/A External Id：CHEMBL3117023

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