匙羹藤酸I

• 常用名: 匙羹藤酸I
• 英文名: Gymnemic acid I
• CAS号: 122168-40-5
• 分子量: 806.976
• 密度: 1.3±0.1 g/cm3
• 沸点: 872.1±65.0 °C at 760 mmHg
• 分子式: C₄₃H₆₆O₁₄
• 熔点: N/A
• 闪点: 252.8±27.8 °C

匙羹藤酸I用途

Gymnemic acid I 是存在 Gymnema sylvestre 中的一种具有活性的三萜皂苷。Gymnemic acid I 能减少细胞在高糖应激下凋亡。

匙羹藤酸I名称

• 中文名: 匙羹藤酸I
• 英文名: (2S,3S,4S,5R,6R)-6-[[(3S,4R,4aR,6aR,6bS,8S,8aR,9R,10R,12aS,14aR,14bR)-8a-(acetyloxymethyl)-8,9-dihydroxy-4-(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(E)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5

匙羹藤酸I生物活性

• 描述: Gymnemic acid I 是存在 Gymnema sylvestre 中的一种具有活性的三萜皂苷。Gymnemic acid I 能减少细胞在高糖应激下凋亡。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Capolupo A, et al. Determination of Gymnemic Acid I as a Protein Biosynthesis Inhibitor Using Chemical Proteomics. J Nat Prod. 2017 Apr 28;80(4):909-915.

  [2]. Wu Y, et al. Gymnemic acid I triggers mechanistic target of rapamycin-mediated β cells cytoprotection through the promotion of autophagy under high glucose stress. J Cell Physiol. 2019 Jun;234(6):9370-9377.

匙羹藤酸I物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 872.1±65.0 °C at 760 mmHg
• 分子式: C₄₃H₆₆O₁₄
• 分子量: 806.976
• 闪点: 252.8±27.8 °C
• 精确质量: 806.445251
• PSA: 229.74000
• LogP: 4.74
• InChIKey: VEFSVJGWJQPWFS-ZXKKMYOJSA-N
• SMILES: CC=C(C)C(=O)OC1C(O)C2(COC(C)=O)C(O)CC3(C)C(=CCC4C5(C)CCC(OC6OC(C(=O)O)C(O)C(O)C6O)C(C)(CO)C5CCC43C)C2CC1(C)C
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.596

匙羹藤酸I靶点实验

查看更多实验

实验名称：Binding affinity to heat shock cognate 71 kDa protein in human Hela cells lysates ass... 来源：ChEMBL 靶标：Heat shock cognate 71 kDa protein External Id：CHEMBL4270836

实验名称：Binding affinity to GTP-binding nuclear protein ran in human Hela cells lysates asses... 来源：ChEMBL 靶标：GTP-binding nuclear protein Ran External Id：CHEMBL4270835

实验名称：Binding affinity to histone H2A in human Hela cells lysates assessed as protein enric... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4270838

实验名称：Binding affinity to heat shock protein 90-beta in human Hela cells lysates assessed a... 来源：ChEMBL 靶标：Heat shock protein HSP 90-beta External Id：CHEMBL4270837

实验名称：Binding affinity to eukaryotic initiation factor 4A-II in human Hela cells lysates as... 来源：ChEMBL 靶标：Eukaryotic initiation factor 4A-II External Id：CHEMBL4270832

实验名称：Binding affinity to elongation factor 2 in human Hela cells lysates assessed as prote... 来源：ChEMBL 靶标：Elongation factor 2 External Id：CHEMBL4270831

实验名称：Binding affinity to glyceraldehyde-3-phosphate dehydrogenase in human Hela cells lysa... 来源：ChEMBL 靶标：Glyceraldehyde-3-phosphate dehydrogenase External Id：CHEMBL4270834

实验名称：Binding affinity to eukaryotic translation initiation factor in human Hela cells lysa... 来源：ChEMBL 靶标：Elongation factor 2 External Id：CHEMBL4270833

实验名称：Binding affinity to poly(rC)-binding protein 2 in human Hela cells lysates assessed a... 来源：ChEMBL 靶标：Poly(rC)-binding protein 2 External Id：CHEMBL4270844

实验名称：Binding affinity to phosphoglycerate kinase 1 in human Hela cells lysates assessed as... 来源：ChEMBL 靶标：Phosphoglycerate kinase 1 External Id：CHEMBL4270843

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匙羹藤酸I英文别名

• (3β,16β,21β,22α)-28-Acetoxy-16,22,23-trihydroxy-21-{[(2E)-2-methylbut-2-enoyl]oxy}olean-12-en-3-yl β-D-glucopyranosiduronic acid
• gymnemic acid I
• (3β,16β,21β,22α)-28-Acetoxy-16,22,23-trihydroxy-21-{[(2E)-2-methyl-2-butenoyl]oxy}olean-12-en-3-yl β-D-glucopyranosiduronic acid