4-[[1-(4-Cyanophenyl)piperidin-4-yl]amino]-6-[(2-methylpyrimidin-4-yl)amino]pyridine-3-carboxamide

• 常用名: 4-[[1-(4-Cyanophenyl)piperidin-4-yl]amino]-6-[(2-methylpyrimidin-4-yl)amino]pyridine-3-carboxamide
• 英文名: 4-[[1-(4-Cyanophenyl)piperidin-4-yl]amino]-6-[(2-methylpyrimidin-4-yl)amino]pyridine-3-carboxamide
• CAS号: 1227481-70-0
• 分子量: 428.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₂₄N₈O
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 4-[[1-(4-Cyanophenyl)piperidin-4-yl]amino]-6-[(2-methylpyrimidin-4-yl)amino]pyridine-3-carboxamide

物理化学性质

• 分子式: C₂₃H₂₄N₈O
• 分子量: 428.5
• InChIKey: DIAXGSXBDZNLPK-UHFFFAOYSA-N
• SMILES: Cc1nccc(Nc2cc(NC3CCN(c4ccc(C#N)cc4)CC3)c(C(N)=O)cn2)n1

靶点实验

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实验名称：Immunomodulatory activity in ACI-to-Lewis rat heterotopic cardiac transplant model as... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4429525

实验名称：Inhibition of human JAK3 assessed as reduction in phosphorylation of Biotin-Lyn-Subst... 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK3 External Id：CHEMBL4429526

实验名称：Inhibition of human JAK1 assessed as reduction in phosphorylation of Biotin-Lyn-Subst... 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK1 External Id：CHEMBL4429527

实验名称：Inhibition of human JAK2 assessed as reduction in phosphorylation of Biotin-Lyn-Subst... 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK2 External Id：CHEMBL4429528

实验名称：Inhibition of human ERG expressed in CHO-K1 cells after 10 mins by Rb efflux assay 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL4429529

实验名称：Half life in rat at 1 mg/kg, iv 来源：ChEMBL 靶标：N/A External Id：CHEMBL4429562

实验名称：Volume of distribution at steady state in rat at 1 mg/kg, iv 来源：ChEMBL 靶标：N/A External Id：CHEMBL4429563

实验名称：Total clearance in rat at 1 mg/kg, iv 来源：ChEMBL 靶标：N/A External Id：CHEMBL4429564

实验名称：Tmax in rat at 1 mg/kg, po 来源：ChEMBL 靶标：N/A External Id：CHEMBL4429566

实验名称：AUC (0 to 24 hrs) in rat at 1 mg/kg, po 来源：ChEMBL 靶标：N/A External Id：CHEMBL4429567

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