7-(2-Methyl-6-(4h-1,2,4-triazol-3-yl)pyridin-3-yl)-1-(2-(tetrahydro-2h-pyran-4-yl)ethyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one

• 常用名: 7-(2-Methyl-6-(4h-1,2,4-triazol-3-yl)pyridin-3-yl)-1-(2-(tetrahydro-2h-pyran-4-yl)ethyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
• 英文名: 7-(2-Methyl-6-(4h-1,2,4-triazol-3-yl)pyridin-3-yl)-1-(2-(tetrahydro-2h-pyran-4-yl)ethyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
• CAS号: 1228013-49-7
• 分子量: 420.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₄N₈O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 7-(2-Methyl-6-(4h-1,2,4-triazol-3-yl)pyridin-3-yl)-1-(2-(tetrahydro-2h-pyran-4-yl)ethyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one

物理化学性质

• 分子式: C₂₁H₂₄N₈O₂
• 分子量: 420.5
• InChIKey: VLSSMLSPCKXABU-UHFFFAOYSA-N
• SMILES: Cc1nc(-c2ncn[nH]2)ccc1-c1cnc2c(n1)N(CCC1CCOCC1)C(=O)CN2

靶点实验

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实验名称：Ratio of Cmax in rat at 5 mg/kg, po to IC50 for mTORC2 in human PC3 cells assessed as... 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL3587844

实验名称：Selectivity ratio of IC50 for PI3K-alpha (unknown origin) to IC50 for mTOR (unknown o... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3587372

实验名称：Ratio of AUC (0 to infinity) in rat at 5 mg/kg, po to IC50 for mTORC2 in human PC3 ce... 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL3587909

实验名称：Mean residence time in rat at 2 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3587842

实验名称：Oral bioavailability in rat at 5 mg/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3587843

实验名称：Inhibition of mTORC2 in human PC3 cells assessed as inhibition of AKT phosphorylation... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3587517

实验名称：Cmax in rat at 5 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3587518

实验名称：Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assay 来源：ChEMBL 靶标：Serine/threonine-protein kinase mTOR External Id：CHEMBL3587521

实验名称：Inhibition of mTORC1 in human PC3 cells assessed as inhibition of p70S6K phosphorylat... 来源：ChEMBL 靶标：Target of rapamycin complex subunit LST8 External Id：CHEMBL3587522

实验名称：Tmax in rat at 5 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3587519

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