5,6-Diethyl-2-{5-[(4-Methylpiperazin-1-Yl)sulfonyl]-2-Propoxyphenyl}pyrimidin-4(3h)-One

• 常用名: 5,6-Diethyl-2-{5-[(4-Methylpiperazin-1-Yl)sulfonyl]-2-Propoxyphenyl}pyrimidin-4(3h)-One
• 英文名: 5,6-Diethyl-2-{5-[(4-Methylpiperazin-1-Yl)sulfonyl]-2-Propoxyphenyl}pyrimidin-4(3h)-One
• CAS号: 1229017-26-8
• 分子量: 448.6
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₃₂N₄O₄S
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 5,6-Diethyl-2-{5-[(4-Methylpiperazin-1-Yl)sulfonyl]-2-Propoxyphenyl}pyrimidin-4(3h)-One

物理化学性质

• 分子式: C₂₂H₃₂N₄O₄S
• 分子量: 448.6
• InChIKey: FJJLJIBQQGUEHI-UHFFFAOYSA-N
• SMILES: CCCOc1ccc(S(=O)(=O)N2CCN(C)CC2)cc1-c1nc(CC)c(CC)c(=O)[nH]1

靶点实验

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实验名称：Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximi... 来源：ChEMBL 靶标：cGMP-specific 3',5'-cyclic phosphodiesterase External Id：CHEMBL2184512

实验名称：Inhibition of N-terminal GST-tagged human PDE5A1 expressed in baculovirus infected sf... 来源：ChEMBL 靶标：cGMP-specific 3',5'-cyclic phosphodiesterase External Id：CHEMBL4397429

实验名称：Selectivity index, ratio of IC50 for human recombinant PDE6C to IC50 for human recomb... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2184511

实验名称：Selectivity ratio of IC50 for N-terminal GST-tagged human PDE6C to IC50 for N-termina... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4397431

实验名称：Metabolic stability in human liver microsomes assessed as parent compound remaining a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4397432

实验名称：Increase in intracavernous pressure/blood pressure in Sprague-Dawley rat model of ere... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2182849

实验名称：Oral bioavailability in Sprague-Dawley rat at 10 mg/kg by LC-MS/MS method 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2182850

实验名称：MRT (0 to 10 hrs) in Sprague-Dawley rat at 5 mg/kg, iv by LC-MS/MS method 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2184496

实验名称：Volume of distribution in Sprague-Dawley rat at 5 mg/kg, iv by LC-MS/MS method 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2184497

实验名称：Half life in Sprague-Dawley rat at 5 mg/kg, iv by LC-MS/MS method 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2184494

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