2-[4-(4-{7-[2-(Methanesulfonyl-methyl-amino)-phenyl]-5-methyl-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino}-3-methoxy-phenyl)-piperidin-1-yl]-acetamide

• 常用名: 2-[4-(4-{7-[2-(Methanesulfonyl-methyl-amino)-phenyl]-5-methyl-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino}-3-methoxy-phenyl)-piperidin-1-yl]-acetamide
• 英文名: 2-[4-(4-{7-[2-(Methanesulfonyl-methyl-amino)-phenyl]-5-methyl-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino}-3-methoxy-phenyl)-piperidin-1-yl]-acetamide
• CAS号: 1233180-64-7
• 分子量: 577.7
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₃₅N₇O₄S
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 2-[4-(4-{7-[2-(Methanesulfonyl-methyl-amino)-phenyl]-5-methyl-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino}-3-methoxy-phenyl)-piperidin-1-yl]-acetamide

物理化学性质

• 分子式: C₂₉H₃₅N₇O₄S
• 分子量: 577.7
• InChIKey: INVMLEPLZRDFOO-UHFFFAOYSA-N
• SMILES: COc1cc(C2CCN(CC(N)=O)CC2)ccc1Nc1ncc2c(C)cc(-c3ccccc3N(C)S(C)(=O)=O)n2n1

靶点实验

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实验名称：Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assa... 来源：ChEMBL 靶标：ALK tyrosine kinase receptor External Id：CHEMBL2162287

实验名称：Half life in CD1 mouse liver microsomes at 0.5 uM preincubated for 10 mins before NAD... 来源：ChEMBL 靶标：Liver External Id：CHEMBL2162288

实验名称：Half life in monkey liver microsomes at 0.5 uM preincubated for 10 mins before NADPH ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2161944

实验名称：Half life in human liver microsomes at 0.5 uM preincubated for 10 mins before NADPH a... 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL2161945

实验名称：Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 i... 来源：ChEMBL 靶标：ALK tyrosine kinase receptor External Id：CHEMBL2161942

实验名称：Half life in Sprague-Dawley rat liver microsomes at 0.5 uM preincubated for 10 mins b... 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL2161943

实验名称：Oral bioavailability in Sprague-Dawley rat at 5 mg/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2161948

实验名称：Drug metabolism in human liver microsomes assessed as glutathione-compound covalent a... 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL2162286

实验名称：Half life in Sprague-Dawley rat at 1 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2161946

实验名称：Selectivity index, ratio of IC50 for insulin receptor to IC50 for GST-tagged human AL... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2162267

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