Ifidancitinib

• 常用名: Ifidancitinib
• 英文名: Ifidancitinib
• CAS号: 1236667-40-5
• 分子量: 395.39
• 密度: 1.5±0.1 g/cm3
• 沸点: 1003.0±65.0 °C at 760 mmHg
• 分子式: C₂₀H₁₈FN₅O₃
• 熔点: N/A
• 闪点: 560.4±34.3 °C

Ifidancitinib用途

Ifidancitinib是JAK激酶1/3的有效和选择性抑制剂。Ifidancitinib可用于过敏、哮喘和自身免疫性疾病的研究[1]。

Ifidancitinib名称

• 英文名: N-(4-{[(6S)-4-Hydroxy-2-(hydroxymethyl)-7,8-dihydro-6H-cyclopenta[g]quinazolin-6-yl](2-propyn-1-yl)amino}benzoyl)-γ-glutamylglutamic acid

Ifidancitinib生物活性

• 描述: Ifidancitinib是JAK激酶1/3的有效和选择性抑制剂。Ifidancitinib可用于过敏、哮喘和自身免疫性疾病的研究[1]。
• 相关类别:
  信号通路 >> JAK/STAT信号通路 >> JAK
  信号通路 >> 表观遗传学 >> JAK
  信号通路 >> 干细胞及 Wnt 通路 >> JAK
  研究领域 >> 其他
• 参考文献:

  [1]. Li, Hui; Heckrodt, Thilo J.; Chen, Yan; Mcmurtrie, Darren John; Taylor, Vanessa; Singh, Rajinder; Ding, Pingyu; Yen, Rose.Preparation of phenylaminopyrimidinylaminooxobenzooxazole derivatives for use as JAK kinase inhibitors. WO2012015972A1

Ifidancitinib物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 1003.0±65.0 °C at 760 mmHg
• 分子式: C₂₀H₁₈FN₅O₃
• 分子量: 395.39
• 闪点: 560.4±34.3 °C
• 精确质量: 647.222717
• LogP: -1.15
• InChIKey: OYFMQDVLFYKOPZ-UHFFFAOYSA-N
• SMILES: COc1cc(Nc2ncc(C)c(Nc3ccc4oc(=O)[nH]c4c3)n2)cc(C)c1F
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.693

Ifidancitinib靶点实验

查看更多实验

实验名称：Inhibition of CYP2D6 (unknown origin) 来源：ChEMBL 靶标：Cytochrome P450 2D6 External Id：CHEMBL5120635

实验名称：Inhibition of CYP2C19 (unknown origin) 来源：ChEMBL 靶标：Cytochrome P450 2C19 External Id：CHEMBL5120636

实验名称：Selectivity ratio of IC50 for inhibition of JAK2 signaling pathway in EPO-stimulated ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5120630

实验名称：Inhibition of IL-2 stimulated IFN-gamma production in BALB/c mouse at 5 mg/kg, po pre... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5120631

实验名称：Inhibition of CYP3A4 (unknown origin) in absence of NADPH 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL5120632

实验名称：Inhibition of CYP3A4 (unknown origin) in presence of NADPH 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL5120633

实验名称：Inhibition of IL-2 stimulated IFN-gamma production in BALB/c mouse at 40 mg/kg, po pr... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5120628

实验名称：Inhibition of JAK2 signaling pathway in human CHEP cells assessed as inhibition of EP... 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK2 External Id：CHEMBL5120629

实验名称：Inhibition of human full length recombinant N-terminal GST-tagged SYK expressed in ba... 来源：ChEMBL 靶标：Tyrosine-protein kinase SYK External Id：CHEMBL5120656

实验名称：Inhibition of JAK1/JAK3 in human primary T-cells assessed as reduction of IL-2 stimul... 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK1 External Id：CHEMBL5120624

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Ifidancitinib英文别名

• N-(4-{[(6S)-4-Hydroxy-2-(hydroxymethyl)-7,8-dihydro-6H-cyclopenta[g]quinazolin-6-yl](2-propyn-1-yl)amino}benzoyl)-γ-glutamylglutamic acid