NAB-14

• 常用名: NAB-14
• 英文名: NAB-14
• CAS号: 1237541-73-9
• 分子量: 351.406
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₁N₃O₃
• 熔点: N/A
• 闪点: N/A

NAB-14用途

NAB-14是含有GluN2C/2D的NMDA受体的有效选择性负变构调节剂,IC50为580 nM,对GluN2A/GluN2受体的选择性>800倍；抑制三异聚体(GluN1/GluN2A/GluN2C)NMDAR与二异聚体(GluN1/GluN2C/GluN2C)受体相比,效力和功效适度降低；抑制GluN2D介导的大鼠丘脑底神经元和小鼠海马中间神经元的突触电流,但对海马锥体神经元的突触传递没有影响。

NAB-14名称

• 英文名: NAB-14

NAB-14生物活性

• 描述: NAB-14是含有GluN2C/2D的NMDA受体的有效选择性负变构调节剂,IC50为580 nM,对GluN2A/GluN2受体的选择性>800倍；抑制三异聚体(GluN1/GluN2A/GluN2C)NMDAR与二异聚体(GluN1/GluN2C/GluN2C)受体相比,效力和功效适度降低；抑制GluN2D介导的大鼠丘脑底神经元和小鼠海马中间神经元的突触电流,但对海马锥体神经元的突触传递没有影响。
• 参考文献: References 1. Swanger SA, et al. ACS Chem Neurosci. 2018 Feb 21;9(2):306-319. View Related Products by Target iGluR

NAB-14物理化学性质

• 分子式: C₂₀H₂₁N₃O₃
• 分子量: 351.406
• InChIKey: WCGIKJOMEYPSIP-UHFFFAOYSA-N
• SMILES: CCN(CC)C(=O)Oc1ccc(C(=O)Nc2cccc3cc[nH]c23)cc1
• 储存条件: -20°C，密闭，干燥

NAB-14靶点实验

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实验名称：Negative allosteric modulation of human GluA3 L513Y mutant expressed in Xenopus laevi... 来源：ChEMBL 靶标：Glutamate receptor 3 External Id：CHEMBL4339638

实验名称：Negative allosteric modulation of recombinant rat GluN1/GluN2C expressed in Xenopus l... 来源：ChEMBL 靶标：Glutamate receptor ionotropic, NMDA 1 External Id：CHEMBL4339621

实验名称：Negative allosteric modulation of human GluA2 R607Q mutant expressed in Xenopus laevi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4339637

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