1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxyic acid

• 常用名: 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxyic acid
• 英文名: 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxyic acid
• CAS号: 123942-05-2
• 分子量: 370.34900
• 密度: 1.459g/cm3
• 沸点: 506.7ºC at 760mmHg
• 分子式: C₂₀H₁₆F₂N₂O₃
• 熔点: N/A
• 闪点: 260.2ºC

名称

• 英文名: 1-cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-4-oxoquinoline-3-carboxylic acid

物理化学性质

• 密度: 1.459g/cm3
• 沸点: 506.7ºC at 760mmHg
• 分子式: C₂₀H₁₆F₂N₂O₃
• 分子量: 370.34900
• 闪点: 260.2ºC
• 精确质量: 370.11300
• PSA: 72.19000
• LogP: 3.99160
• InChIKey: WHXJSJBKDGZVDA-UHFFFAOYSA-N
• SMILES: Cc1cc(-c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2F)cc(C)n1
• 蒸汽压: 4.35E-11mmHg at 25°C
• 折射率: 1.645

靶点实验

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实验名称：In vivo antitumor activity was measured as the maximum dose tolerated by murine when ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL739991

实验名称：In vitro cytotoxicity against P388 mouse leukemia cells 来源：ChEMBL 靶标：P388 External Id：CHEMBL754900

实验名称：Minimum Inhibitory concentration measured against Escherichia coli ATCC 1-25922 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL678958

实验名称：Inhibition of calf thymus DNA/ethidium bromide complex formation. 来源：ChEMBL 靶标：DNA topoisomerase 2-beta External Id：CHEMBL660972

实验名称：Minimum Inhibitory concentration measured against Staphylococcus aureus ATCC 29213 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL806924

实验名称：In vitro cytotoxicity was evaluated following 1 hour transient exposure of P388 mouse... 来源：ChEMBL 靶标：P388 External Id：CHEMBL757881

实验名称：Minimum Inhibitory concentration measured against Streptococcus faecalis ATCC 29212 来源：ChEMBL 靶标：Enterococcus faecalis External Id：CHEMBL812354

实验名称：Inhibitory activity in a cell-free assay of DNA cleavage mediated by purified HeLa ce... 来源：ChEMBL 靶标：DNA topoisomerase 2-beta External Id：CHEMBL847692

实验名称：Minimum Inhibitory concentration measured against Pseudomonas aeruginosa ATCC 27853 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL762961

实验名称：Minimum Inhibitory concentration measured against Streptococcus pyogenes ATCC 6301 来源：ChEMBL 靶标：Streptococcus pyogenes External Id：CHEMBL809201

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英文别名

• Cpfdm-3-qca
• 1-Cyclopropyl-7-(2,6-dimethyl-4-pyridinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
• 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid
• 8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
• 1-cyclopropyl-6,8-difluoro-7-(2,6-dimethyl-4-pyridinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
• 1-cyclopropyl-7-(2,6-dimethyl-4-pyridinyl)-6
• 6-dimethyl-4-pyridinyl)-6
• 1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxyic acid