PTC725

• 常用名: PTC725
• 英文名: PTC725
• CAS号: 1248581-07-8
• 分子量: 518.487
• 密度: 1.5±0.1 g/cm3
• 沸点: 701.2±70.0 °C at 760 mmHg
• 分子式: C₂₃H₁₈F₄N₆O₂S
• 熔点: N/A
• 闪点: 377.9±35.7 °C

PTC725用途

PTC725是HCV NS4B的有效,选择性和口服生物可利用的抑制剂,抑制HCV 1b(Con1)复制子,EC50为1.7 nM；相对于细胞GAPDH,选择性指数>5000,选择性窗口>1000倍。细胞毒性；保留对对NS3蛋白酶和NS5B聚合酶抑制剂具有抗性的HCV复制子突变体的完全活性,在体内与α干扰素组合显示出协同作用。

PTC725名称

• 英文名: 6-[3-Cyano-6-ethyl-5-fluoro-1-(2-pyrimidinyl)-1H-indol-2-yl]-N-[(2S)-1,1,1-trifluoro-2-propanyl]-3-pyridinesulfonamide

PTC725生物活性

• 描述: PTC725是HCV NS4B的有效,选择性和口服生物可利用的抑制剂,抑制HCV 1b(Con1)复制子,EC50为1.7 nM；相对于细胞GAPDH,选择性指数>5000,选择性窗口>1000倍。细胞毒性；保留对对NS3蛋白酶和NS5B聚合酶抑制剂具有抗性的HCV复制子突变体的完全活性,在体内与α干扰素组合显示出协同作用。
• 参考文献: References 1. Gu Z, et al. Antimicrob Agents Chemother. 2013 Jul;57(7):3250-61. 2. Zhang N, et al. J Med Chem. 2014 Mar 13;57(5):2121-35. 3. Graci JD, et al. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7060-7066. View Related Products by Target HCV

PTC725物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 701.2±70.0 °C at 760 mmHg
• 分子式: C₂₃H₁₈F₄N₆O₂S
• 分子量: 518.487
• 闪点: 377.9±35.7 °C
• 精确质量: 518.114807
• LogP: 4.28
• InChIKey: OBULGMCFXOTNNK-ZDUSSCGKSA-N
• SMILES: CCc1cc2c(cc1F)c(C#N)c(-c1ccc(S(=O)(=O)NC(C)C(F)(F)F)cn1)n2-c1ncccn1
• 蒸汽压: 0.0±2.2 mmHg at 25°C
• 折射率: 1.638

PTC725靶点实验

查看更多实验

实验名称：AUC (0 to infinity) in Sprague-Dawley rat at 10 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3123240

实验名称：Drug metabolism in bile duct cannulated rat assessed as 6-(3-cyano-5-fluoro-6-(1-hydr... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3123241

实验名称：Drug metabolism in bile duct cannulated rat assessed as 6-(3-cyano-5-fluoro-6-(1-hydr... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3123242

实验名称：Antiviral activity against HCV1b infected in clone A and ET-lunet cells assessed as i... 来源：ChEMBL 靶标：Hepacivirus hominis External Id：CHEMBL3122933

实验名称：Drug metabolism in bile duct cannulated rat assessed as 6-(3-cyano-6-ethyl-5-fluoro-1... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3123243

实验名称：AUC (0 to infinity) in CRL-CD-BR rat at 10 mg/kg, po by LC-MS/MS analysis 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3756720

实验名称：Toxicity in rat up to 2000 mg/kg/day 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3123244

实验名称：Drug metabolism in bile duct cannulated monkey assessed as GSH adduct formation 来源：ChEMBL 靶标：Macaca mulatta External Id：CHEMBL3123247

实验名称：Ratio of plasma concentration in cynomolgus monkey at 8 hrs to EC50 for antiviral act... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3756740

实验名称：Ratio of plasma concentration in beagle dog at 8 hrs to EC50 for antiviral activity a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3756739

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PTC725英文别名

• 6-[3-Cyano-6-ethyl-5-fluoro-1-(2-pyrimidinyl)-1H-indol-2-yl]-N-[(2S)-1,1,1-trifluoro-2-propanyl]-3-pyridinesulfonamide