右美沙芬结构式
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常用名 | 右美沙芬 | 英文名 | Dextromethorphan |
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CAS号 | 125-71-3 | 分子量 | 271.397 | |
密度 | 1.1±0.1 g/cm3 | 沸点 | 394.9±42.0 °C at 760 mmHg | |
分子式 | C18H25NO | 熔点 | N/A | |
MSDS | N/A | 闪点 | 116.2±30.2 °C | |
符号 |
GHS02, GHS06, GHS08 |
信号词 | Danger |
右美沙芬用途Dextromethorphan is a dextratrorotatory morphinan, binds to and inhibits NMDA and nicotinic receptor and blocks receptor-gated and voltage-gated calcium channels and voltage-gated sodium channels. |
中文名 | 右美沙芬 |
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英文名 | dextromethorphan |
中文别名 | 右甲吗喃 |
英文别名 | 更多 |
密度 | 1.1±0.1 g/cm3 |
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沸点 | 394.9±42.0 °C at 760 mmHg |
分子式 | C18H25NO |
分子量 | 271.397 |
闪点 | 116.2±30.2 °C |
精确质量 | 271.193604 |
PSA | 12.47000 |
LogP | 4.11 |
蒸汽压 | 0.0±0.9 mmHg at 25°C |
折射率 | 1.585 |
储存条件 | ?20°C |
分子结构 | 五、分子性质数据: 1、 摩尔折射率:81.76 2、 摩尔体积(m3/mol):243.8 3、 等张比容(90.2K):631.2 4、 表面张力(dyne/cm):44.9 5、 极化率(10-24cm3):32.41 |
计算化学 | 1.疏水参数计算参考值(XlogP):无 2.氢键供体数量:0 3.氢键受体数量:2 4.可旋转化学键数量:1 5.互变异构体数量:无 6.拓扑分子极性表面积12.5 7.重原子数量:20 8.表面电荷:0 9.复杂度:370 10.同位素原子数量:0 11.确定原子立构中心数量:3 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1 |
右美沙芬毒理学数据: 急性毒性数据 小孩经口TDLo:16mg/kg 大鼠经口LD50:116mg/kg 大鼠静脉LD50:16286ug/kg 小鼠经口LD50:210mg/kg 小树皮肤LD50:112mg/kg 狗静脉LDLo:22 mg/kg |
符号 |
GHS02, GHS06, GHS08 |
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信号词 | Danger |
危害声明 | H225-H301 + H311 + H331-H370 |
警示性声明 | P210-P260-P280-P301 + P310-P311 |
危害码 (欧洲) | F,T |
风险声明 (欧洲) | 11-23/24/25-39/23/24/25 |
安全声明 (欧洲) | 16-36/37-45 |
危险品运输编码 | 3249 |
包装等级 | III |
危险类别 | 6.1(b) |
右美沙芬上游产品 10 | |
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右美沙芬下游产品 2 | |
Low doses of dextromethorphan have a beneficial effect in the treatment of neuropathic pain.
Fundam. Clin. Pharmacol. 28(6) , 671-80, (2014) N-methyl-D-aspartate receptor (NMDAR) antagonists may be given in persistent neuropathic pain, but adverse events especially with ketamine may limit their clinical use. Less central and cognitive adve... |
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Evaluation of thein vitro/in vivodrug interaction potential of BST204, a purified dry extract of ginseng, and its four bioactive ginsenosides through cytochrome P450 inhibition/induction and UDP-glucuronosyltransferase inhibition
Food Chem. Toxicol. 68 , 117-27, (2014) • BST204 is a purified dry extract of ginseng containing high amounts of Rh2 and Rg3. • BST204 had only weak inhibitory effects on nine CYPs and five UGTs. • It is unlikely that BST204 alter pharmacok... |
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Identification of the rat liver cytochrome P450 enzymes involved in the metabolism of the calcium channel blocker dipfluzine hydrochloride.
Environ. Toxicol. Pharmacol. 38(3) , 901-12, (2014) This study aimed to identify the specific cytochrome P450 (CYP450) enzymes involved in the metabolism of dipfluzine hydrochloride using the combination of a chemical inhibition study, a correlation an... |
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EINECS 204-752-2 |
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Novahistex DM |
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Cough-X |
Delsym Cough Formula |
Dormetan |
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(9a,13a,14a)-3-Methoxy-17-methylmorphinan |
Dextromethorphan (USP) |
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Dextrometorphan |
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Robitussin Pediatric |
Balminil DM |
[14C]-Dextromethorphan |
[3H]-Dextromethorphan |
Benylin Pediatric Cough Suppressant |
3-Methoxy-17-methyl-9a,13a,14a-morphinan |
Pertussin DM Extra Strength |
Koffex DM |
(9α,13α,14α)-17-methyl-3-(methyloxy)morphinan |
Calmylin #1 |
dextromethorpan |
Dextromethorfan [Czech] |
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MFCD00866833 |
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Destrometerfano [DCIT] |
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