右美沙芬

更新时间:2024-01-02 10:01:31

右美沙芬结构式
右美沙芬结构式
品牌特惠专场
常用名 右美沙芬 英文名 Dextromethorphan
CAS号 125-71-3 分子量 271.397
密度 1.1±0.1 g/cm3 沸点 394.9±42.0 °C at 760 mmHg
分子式 C18H25NO 熔点 N/A
MSDS N/A 闪点 116.2±30.2 °C
符号 GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
信号词 Danger

 右美沙芬用途


Dextromethorphan is a dextratrorotatory morphinan, binds to and inhibits NMDA and nicotinic receptor and blocks receptor-gated and voltage-gated calcium channels and voltage-gated sodium channels.

 右美沙芬名称

中文名 右美沙芬
英文名 dextromethorphan
中文别名 右甲吗喃
英文别名 更多

 右美沙芬物理化学性质

密度 1.1±0.1 g/cm3
沸点 394.9±42.0 °C at 760 mmHg
分子式 C18H25NO
分子量 271.397
闪点 116.2±30.2 °C
精确质量 271.193604
PSA 12.47000
LogP 4.11
蒸汽压 0.0±0.9 mmHg at 25°C
折射率 1.585
储存条件 ?20°C
分子结构

五、分子性质数据:

1、 摩尔折射率:81.76

2、 摩尔体积(m3/mol):243.8

3、 等张比容(90.2K):631.2

4、 表面张力(dyne/cm):44.9

5、 极化率(10-24cm3):32.41

计算化学

1.疏水参数计算参考值(XlogP):无

2.氢键供体数量:0

3.氢键受体数量:2

4.可旋转化学键数量:1

5.互变异构体数量:无

6.拓扑分子极性表面积12.5

7.重原子数量:20

8.表面电荷:0

9.复杂度:370

10.同位素原子数量:0

11.确定原子立构中心数量:3

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

 右美沙芬MSDS

 右美沙芬毒性和生态

右美沙芬毒理学数据:

急性毒性数据

小孩经口TDLo:16mg/kg

大鼠经口LD50:116mg/kg

大鼠静脉LD50:16286ug/kg

小鼠经口LD50:210mg/kg

小树皮肤LD50:112mg/kg

狗静脉LDLo:22 mg/kg

右美沙芬毒性英文版

 右美沙芬安全信息

符号 GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
信号词 Danger
危害声明 H225-H301 + H311 + H331-H370
警示性声明 P210-P260-P280-P301 + P310-P311
危害码 (欧洲) F,T
风险声明 (欧洲) 11-23/24/25-39/23/24/25
安全声明 (欧洲) 16-36/37-45
危险品运输编码 3249
包装等级 III
危险类别 6.1(b)

 右美沙芬合成线路

 右美沙芬文献41

更多文献
Low doses of dextromethorphan have a beneficial effect in the treatment of neuropathic pain.

Fundam. Clin. Pharmacol. 28(6) , 671-80, (2014)

N-methyl-D-aspartate receptor (NMDAR) antagonists may be given in persistent neuropathic pain, but adverse events especially with ketamine may limit their clinical use. Less central and cognitive adve...

Evaluation of thein vitro/in vivodrug interaction potential of BST204, a purified dry extract of ginseng, and its four bioactive ginsenosides through cytochrome P450 inhibition/induction and UDP-glucuronosyltransferase inhibition

Food Chem. Toxicol. 68 , 117-27, (2014)

• BST204 is a purified dry extract of ginseng containing high amounts of Rh2 and Rg3. • BST204 had only weak inhibitory effects on nine CYPs and five UGTs. • It is unlikely that BST204 alter pharmacok...

Identification of the rat liver cytochrome P450 enzymes involved in the metabolism of the calcium channel blocker dipfluzine hydrochloride.

Environ. Toxicol. Pharmacol. 38(3) , 901-12, (2014)

This study aimed to identify the specific cytochrome P450 (CYP450) enzymes involved in the metabolism of dipfluzine hydrochloride using the combination of a chemical inhibition study, a correlation an...

 右美沙芬英文别名

Dexyromethorphan
Vicks 44 Cough Relief
Diabe-Tuss DM Syrup
l-Methorphan
Morphinan, 3-methoxy-17-methyl-, (9α,13α,14α)-
Dextrometorfano [INN-Spanish]
Pertussin CS Children's Strength
Robitussin Pediatric Cough Suppressant
Morphinan, 3-methoxy-17-methyl-, (9-α,13-α,14-α)- (9CI)
Trocal
Creo-Terpin
Novahistine DM
(9α,13α,14α)-3-Methoxy-17-methylmorphinan
EINECS 204-752-2
Robitussin Maximum Strength Cough Suppressant
Novahistex DM
(+)-cis-1,3,4,9,10,10a-Hexahydro-6-methoxy-11-methyl-2H-10,4a-iminoethanophenanthren
4-21-00-01367 (Beilstein Handbook Reference)
Cough-X
Delsym Cough Formula
Dormetan
d-Methorphan
(9a,13a,14a)-3-Methoxy-17-methylmorphinan
Dextromethorphan (USP)
Sucrets 4 Hour Cough Suppressant
Dextrometorphan
Demorphine
Hold DM
Triaminic DM Long Lasting for Children
Robitussin Pediatric
Balminil DM
[14C]-Dextromethorphan
[3H]-Dextromethorphan
Benylin Pediatric Cough Suppressant
3-Methoxy-17-methyl-9a,13a,14a-morphinan
Pertussin DM Extra Strength
Koffex DM
(9α,13α,14α)-17-methyl-3-(methyloxy)morphinan
Calmylin #1
dextromethorpan
Dextromethorfan [Czech]
Delsym
MFCD00866833
4-21-00-01367
Destrometerfano [DCIT]
(+)-3-Methoxy-N-methylmorphinon
Dextromorphan
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