N-[3-[(5-ethynyl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide

• 常用名: N-[3-[(5-ethynyl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
• 英文名: N-[3-[(5-ethynyl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
• CAS号: 1254566-87-4
• 分子量: 403.4
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₅F₂N₃O₃S
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-[3-[(5-ethynyl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide

物理化学性质

• 分子式: C₁₉H₁₅F₂N₃O₃S
• 分子量: 403.4
• InChIKey: KZJYXJZFPQXMDG-UHFFFAOYSA-N
• SMILES: C#Cc1cnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)CCC)c3F)c2c1

靶点实验

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实验名称：Cytotoxicity against human SW620 cells expressing Ras mutant assessed as growth inhib... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3880159

实验名称：Antitumor activity against human COLO205 cells xenografted in nu/nu mouse assessed as... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3880160

实验名称：Aqueous solubility of the compound in simulated gastric fluid at pH 1.5 来源：ChEMBL 靶标：N/A External Id：CHEMBL3880161

实验名称：Aqueous solubility of the compound in simulated intestinal fluid at pH 4.5 来源：ChEMBL 靶标：N/A External Id：CHEMBL3880162

实验名称：Inhibition of CYP2C9 (unknown origin) using MFC as substrate after 45 mins 来源：ChEMBL 靶标：Cytochrome P450 2C9 External Id：CHEMBL3880167

实验名称：Binding affinity to wild type full length human JNK1 (M1 to Q384 residues) expressed ... 来源：ChEMBL 靶标：Mitogen-activated protein kinase 8 External Id：CHEMBL4814585

实验名称：Inhibition of CYP2D6 (unknown origin) using AMMC as substrate after 30 mins 来源：ChEMBL 靶标：Cytochrome P450 2D6 External Id：CHEMBL3880168

实验名称：Binding affinity to wild type partial length human ZAK (M1 to L331) expressed in bact... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase 20 External Id：CHEMBL4814586

实验名称：Inhibition of CYP3A4 (unknown origin) using BFC as substrate after 30 mins 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL3880169

实验名称：Binding affinity to GST tagged mouse MKK4 expressed in Escherichia coli expression sy... 来源：ChEMBL 靶标：Dual specificity mitogen-activated protein kinase kinase 4 External Id：CHEMBL4814583

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