6-[(1S)-1-hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methoxypyridine-3-carbonitrile

• 常用名: 6-[(1S)-1-hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methoxypyridine-3-carbonitrile
• 英文名: 6-[(1S)-1-hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methoxypyridine-3-carbonitrile
• CAS号: 1255206-07-5
• 分子量: 452.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₈N₄O₅
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 6-[(1S)-1-hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methoxypyridine-3-carbonitrile

物理化学性质

• 分子式: C₂₄H₂₈N₄O₅
• 分子量: 452.5
• InChIKey: QZUKGDYPSXQBSQ-VXKWHMMOSA-N
• SMILES: COc1cc(C(O)CN2CCN(CC(O)c3ccc4c(c3C)COC4=O)CC2)ncc1C#N

靶点实验

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实验名称：Inhibition of ROMK (unknown origin) expressed in HEK293 cells by thallium flux assay 来源：ChEMBL 靶标：ATP-sensitive inward rectifier potassium channel 1 External Id：CHEMBL3615682

实验名称：Selectivity ratio of IC50 for human ERG to IC50 for ROMK (unknown origin) 来源：ChEMBL 靶标：N/A External Id：CHEMBL3615685

实验名称：Inhibition of human ERG expressed in HEK293 cells by electrophysiology assay 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL3615686

实验名称：Displacement of [35S]-MK499 from human ERG expressed in HEK293 cells 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL3615683

实验名称：Oral bioavailability in Sprague-Dawley rat at 2 mg/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3615693

实验名称：Inhibition of ROMK (unknown origin) expressed in HEK293 cells by electrophysiology as... 来源：ChEMBL 靶标：ATP-sensitive inward rectifier potassium channel 1 External Id：CHEMBL3615694

实验名称：Dose normalized AUC in Sprague-Dawley rat at 2 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3615691

实验名称：Clearance in dog at 0.5 mg/kg, iv and 1 mg/kg, po 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL3615714

实验名称：Fraction unbound in dog plasma 来源：ChEMBL 靶标：Plasma External Id：CHEMBL3615711

实验名称：Oral bioavailability in dog at 1 mg/kg 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL3615717

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