Thiazolo[4,5-d]pyrimidin-7(4H)-one, 5-methyl-4-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-2-(4-morpholinyl)

• 常用名: Thiazolo[4,5-d]pyrimidin-7(4H)-one, 5-methyl-4-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-2-(4-morpholinyl)
• 英文名: Thiazolo[4,5-d]pyrimidin-7(4H)-one, 5-methyl-4-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-2-(4-morpholinyl)
• CAS号: 1256289-67-4
• 分子量: 424.4
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₉F₃N₄O₂S
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: Thiazolo[4,5-d]pyrimidin-7(4H)-one, 5-methyl-4-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-2-(4-morpholinyl)

物理化学性质

• 分子式: C₁₉H₁₉F₃N₄O₂S
• 分子量: 424.4
• InChIKey: REVHYTKYLAMCJQ-UHFFFAOYSA-N
• SMILES: Cc1c(Cn2c(C)nc(=O)c3sc(N4CCOCC4)nc32)cccc1C(F)(F)F

靶点实验

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实验名称：Inhibition of PI3K delta by continuous TR-FRET assay 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform External Id：CHEMBL2090369

实验名称：Selectivity index, ratio of IC50 for human PIK3C2B to IC50 for PI3Kbeta (unknown orig... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4807584

实验名称：Inhibition of PI3K gamma by continuous TR-FRET assay 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform External Id：CHEMBL2090370

实验名称：Inhibition of PI3K alpha by continuous TR-FRET assay 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform External Id：CHEMBL2090266

实验名称：Inhibition of PI3K beta by continuous TR-FRET assay 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform External Id：CHEMBL2090368

实验名称：Inhibition of PI3Kbeta (unknown origin) 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform External Id：CHEMBL2328820

实验名称：Half life in CD mouse at 0.3 mg/kg, iv 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2090373

实验名称：Volume of distribution at steady state in CD mouse at 0.3 mg/kg, iv 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2090374

实验名称：Inhibition of PI3K beta in human PTEN-deficient PC3 cells xenografted in nude mouse a... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2090385

实验名称：Inhibition of PI3K beta in human PTEN-deficient PC3 cells xenografted in nude mouse a... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2090386

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