5-Isoxazolecarboxamide, N-[1-[[[(1R)-1-[4-(3-chloro-1H-indazol-1-yl)-2-fluorophenyl]ethyl]amino]carbonyl]cyclopropyl]-3-methoxy

• 常用名: 5-Isoxazolecarboxamide, N-[1-[[[(1R)-1-[4-(3-chloro-1H-indazol-1-yl)-2-fluorophenyl]ethyl]amino]carbonyl]cyclopropyl]-3-methoxy
• 英文名: 5-Isoxazolecarboxamide, N-[1-[[[(1R)-1-[4-(3-chloro-1H-indazol-1-yl)-2-fluorophenyl]ethyl]amino]carbonyl]cyclopropyl]-3-methoxy
• CAS号: 1259568-41-6
• 分子量: 497.9
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₁ClFN₅O₄
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 5-Isoxazolecarboxamide, N-[1-[[[(1R)-1-[4-(3-chloro-1H-indazol-1-yl)-2-fluorophenyl]ethyl]amino]carbonyl]cyclopropyl]-3-methoxy

物理化学性质

• 分子式: C₂₄H₂₁ClFN₅O₄
• 分子量: 497.9
• InChIKey: FACAUWCDGCSJCP-UHFFFAOYSA-N
• SMILES: COc1cc(C(=O)NC2(C(=O)NC(C)c3ccc(-n4nc(Cl)c5ccccc54)cc3F)CC2)on1

靶点实验

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实验名称：Apparent passive permeability coefficient by cell based assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL1804300

实验名称：Drug transport assessed as MDR1 -mediated transcellular transport ratio by P-gp trans... 来源：ChEMBL 靶标：ATP-dependent translocase ABCB1 External Id：CHEMBL1804299

实验名称：Half life in Sprague-Dawley rat at 10 mg/kg, po or 2 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1804302

实验名称：Oral bioavailability in Sprague-Dawley rat at 10 mg/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1804301

实验名称：Half life in Mongrel dog at 3 mg/kg, po or 1 mg/kg, iv 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL1804304

实验名称：Clearance in Sprague-Dawley rat at 10 mg/kg, po or 2 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1804303

实验名称：Clearance in Mongrel dog at 3 mg/kg, po or 1 mg/kg, iv 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL1804305

实验名称：Displacement of radioligand from human CB1 receptor expressed in CHO cells 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL1804296

实验名称：Displacement of radioligand from human CB2 receptor expressed in CHO cells 来源：ChEMBL 靶标：Cannabinoid receptor 2 External Id：CHEMBL1804297

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