ARN-5187

• 常用名: ARN-5187
• 英文名: ARN-5187
• CAS号: 1287451-26-6
• 分子量: 397.538
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₃₂FN₃O
• 熔点: N/A
• 闪点: N/A

ARN-5187用途

一种新型溶酶体REV-ERB配体,对REV-ERB介导的转录调控和自噬具有双重抑制活性；减轻REV-ERB介导的转录抑制,显着增加处理细胞中自噬相关蛋白p62；破坏溶酶体功能,阻断自噬过程在后期,和降低癌细胞活力；一种比氯喹更具细胞毒性的新型双自噬/REV-ERB抑制剂。

ARN-5187名称

• 英文名: ARN-5187

ARN-5187生物活性

• 描述: 一种新型溶酶体REV-ERB配体,对REV-ERB介导的转录调控和自噬具有双重抑制活性；减轻REV-ERB介导的转录抑制,显着增加处理细胞中自噬相关蛋白p62；破坏溶酶体功能,阻断自噬过程在后期,和降低癌细胞活力；一种比氯喹更具细胞毒性的新型双自噬/REV-ERB抑制剂。
• 参考文献: References 1. De Mei C, et al. Oncogene. 2015 May 14;34(20):2597-608. View Related Products by Target Autophagy

ARN-5187物理化学性质

• 分子式: C₂₄H₃₂FN₃O
• 分子量: 397.538
• InChIKey: RMYLFPZPIDTXQK-UHFFFAOYSA-N
• SMILES: CN1CCN(Cc2cc(CNC3(c4ccccc4F)CCCC3)ccc2O)CC1

ARN-5187靶点实验

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实验名称：Cytotoxicity against human BT474 cells assessed as reduction in cell number incubated... 来源：ChEMBL 靶标：BT-474 External Id：CHEMBL3590982

实验名称：Inhibition of REV-ERBbeta (unknown origin) expressed in HEK293 cells incubated for 24... 来源：ChEMBL 靶标：Nuclear receptor subfamily 1 group D member 2 External Id：CHEMBL3590985

实验名称：Inhibition of autophagy in human BT474 cells assessed as increase in LC3-II protein l... 来源：ChEMBL 靶标：BT-474 External Id：CHEMBL3590986

实验名称：Cytotoxicity against HMEC cells assessed as reduction in cell number incubated for 72... 来源：ChEMBL 靶标：HMEC External Id：CHEMBL3590983

实验名称：Lysosomotropic activity in human BT474 cells assessed as reduction in lysosomal pH in... 来源：ChEMBL 靶标：BT-474 External Id：CHEMBL3590984

实验名称：Dissociation constant, pKa of compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL4308977

实验名称：Inhibition of REV-ERBbeta in human BT474 cells assessed as reduction in BMAL1 express... 来源：ChEMBL 靶标：Nuclear receptor subfamily 1 group D member 2 External Id：CHEMBL3590987

实验名称：Toxicity against human BT474 cells assessed as reduction in cell number at 10 uM incu... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3590988

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