SEN461

• 常用名: SEN461
• 英文名: SEN461
• CAS号: 1287727-28-9
• 分子量: 486.56
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₃₄N₄O₆
• 熔点: N/A
• 闪点: N/A

SEN461用途

SEN461是一种wnt抑制剂。

SEN461名称

• 英文名: SEN461

SEN461生物活性

• 描述: SEN461是一种wnt抑制剂。
• 参考文献: 1. Nencini A, Pratelli C, Quinn JM, Salerno M, Tunici P, De Robertis A, Valensin S, Mennillo F, Rossi M, Bakker A, Benicchi T, Cappelli F, Turlizzi E, Nibbio M, Caradonna NP, Zanelli U, Andreini M, Magnani M, Varrone M. Structure-activity relationship and properties optimization of a series of quinazoline-2,4-diones as inhibitors of the canonical Wnt pathway. Eur J Med Chem. 2015 May 5;95:526-45. doi: 10.1016/j.ejmech.2015.03.055. Epub 2015 Mar 25. PubMed PMID: 25847770.

SEN461物理化学性质

• 分子式: C₂₅H₃₄N₄O₆
• 分子量: 486.56
• InChIKey: CYIHQUXKBWFESS-UHFFFAOYSA-N
• SMILES: COCC(=O)N1CCN(C(=O)C2CCC(Cn3c(=O)c4cc(OC)ccc4n(C)c3=O)CC2)CC1

SEN461靶点实验

查看更多实验

实验名称：Ratio of drug level in brain to plasma in CD1 mouse at 5 mg/kg, po 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3424883

实验名称：Toxicity in human NCI-N87 cells xenografted SCID mouse at 250 mg/kg, po qd for 14 day... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3424884

实验名称：AUC (0 to infinity) in CD1 mouse at 5 mg/kg, po 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3424881

实验名称：Oral bioavailability in CD1 mouse at 5 mg/kg 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3424882

实验名称：In vivo antitumor activity against human NCI-N87 cells xenografted SCID mouse assesse... 来源：ChEMBL 靶标：NCI-N87 External Id：CHEMBL3424887

实验名称：In vivo antitumor activity against human NCI-N87 cells xenografted SCID mouse assesse... 来源：ChEMBL 靶标：NCI-N87 External Id：CHEMBL3424888

实验名称：Toxicity in human NCI-N87 cells xenografted po dosed SCID mouse qd for 14 days 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3424885

实验名称：In vivo antitumor activity against human NCI-N87 cells xenografted SCID mouse assesse... 来源：ChEMBL 靶标：NCI-N87 External Id：CHEMBL3424886

实验名称：AUC in SCID mouse at 100 mg/kg, po qd for 14 days 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3424892

实验名称：Tmax in SCID mouse at 100 mg/kg, po qd for 14 days 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3424895

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