VU0361747

• 常用名: VU0361747
• 英文名: VU0361747
• CAS号: 1309976-66-6
• 分子量: 324.35
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₇FN₂O₂
• 熔点: N/A
• 闪点: N/A

VU0361747用途

VU0361747是代谢型谷氨酸受体亚型5(mGlu5)的阳性变构调节剂(PAM)。

VU0361747名称

• 英文名: VU0361747

VU0361747生物活性

• 描述: VU0361747是代谢型谷氨酸受体亚型5(mGlu5)的阳性变构调节剂(PAM)。
• 参考文献: 1. Rook JM, Noetzel MJ, Pouliot WA, Bridges TM, Vinson PN, Cho HP, Zhou Y, Gogliotti RD, Manka JT, Gregory KJ, Stauffer SR, Dudek FE, Xiang Z, Niswender CM, Daniels JS, Jones CK, Lindsley CW, Conn PJ. Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity. Biol Psychiatry. 2013 Mar 15;73(6):501-9. doi: 10.1016/j.biopsych.2012.09.012. Epub 2012 Nov 7. PubMed PMID: 23140665; PubMed Central PMCID: PMC3572342.

VU0361747物理化学性质

• 分子式: C₁₉H₁₇FN₂O₂
• 分子量: 324.35

VU0361747靶点实验

查看更多实验

实验名称：Optimization of novel mGluR5 positive allosteric modulators with different mechanisms... 来源：Vanderbilt Specialized Chemistry Center 靶标：metabotropic glutamate receptor 5 [Rattus norvegicus] External Id：mGlu5_PAM_SecondaryAssay1

实验名称：Rat mGlu5 receptor (Metabotropic glutamate receptors) 来源：IUPHAR-DB 靶标：mGlu5 receptor (Metabotropic glutamate receptors) [Rattus norvegicus] External Id：293_Rat

实验名称：Positive allosteric modulation of rat mGluR5 来源：ChEMBL 靶标：Metabotropic glutamate receptor 5 External Id：CHEMBL2433918

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