LY2979165

• 常用名: LY2979165
• 英文名: LY2979165
• CAS号: 1311385-32-6
• 分子量: 390.415
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₃H₂₂N₆O₆S
• 熔点: N/A
• 闪点: N/A

LY2979165用途

LY2979165是mGlu2激动剂，是抗抑郁新型化合物。

LY2979165名称

• 中文名: LY2979165
• 英文名: (1R,2R,4S,5R,6R)-4-[[(2S)-2-aminopropanoyl]amino]-2-(1H-1,2,4-triazol-5-ylsulfanyl)bicyclo[3.1.0]hexane-4,6-dicarboxylic acid, azane, hydrate

LY2979165生物活性

• 描述: LY2979165是mGlu2激动剂,是抗抑郁新型化合物。
• 相关类别:
  研究领域 >> 神经疾病
• 参考文献:

  [1]. http://clinicaltrials.gov/ct2/show/NCT01383967

  [2]. Hanna L, Ceolin L, Lucas S, Monn J, Johnson B, Collingridge G, Bortolotto Z, Lodge D.Differentiating the roles of mGlu2 and mGlu3 receptors using LY541850, an mGlu2 agonist/mGlu3 antagonist.Neuropharmacology. 2012 Mar 15.

  [3]. Ceolin L, Kantamneni S, Barker GR, Hanna L, Murray L, Warburton EC, Robinson ES, Monn JA, Fitzjohn SM, Collingridge GL, Bortolotto ZA, Lodge D.Study of novel selective mGlu2 agonist in the temporo-ammonic input to CA1 neurons reveals reduced mGlu2 recepto

  [4]. Liu W, Downing AC, Munsie LM, Chen P, Reed MR, Ruble CL, Landschulz KT, Kinon BJ, Nisenbaum LK.Pharmacogenetic analysis of the mGlu2/3 agonist LY2140023 monohydrate in the treatment of schizophrenia.Pharmacogenomics J. 2012 Jun;12(3):246-54.

  [5]. Dominguez C, Prieto L, Valli MJ, Massey SM, Bures M, Wright RA, Johnson BG, Andis SL, Kingston A, Schoepp DD, Monn JA.Methyl substitution of 2-aminobicyclo[3.1.0]hexane 2,6-dicarboxylate (LY354740) determines functional activity at metabotropic glutamate

LY2979165物理化学性质

• 分子式: C₁₃H₂₂N₆O₆S
• 分子量: 390.415
• 精确质量: 390.132141
• PSA: 212.55000
• LogP: 0.70290
• 储存条件: 2-8℃

LY2979165英文别名

• CS-0457
• Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-[[(2S)-2-amino-1-oxopropyl]amino]-4-(4H-1,2,4-triazol-3-ylthio)-, ammonium salt, (1R,2S,4R,5R,6R)-, hydrate (1:1)
• mGlu2 agonist
• (1R,2S,4R,5R,6R)-2-(L-Alanylamino)-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid ammoniate hydrate
• LY2979165