AMZ30

• 常用名: AMZ30
• 英文名: AMZ30
• CAS号: 1313613-09-0
• 分子量: 461.444
• 密度: 1.5±0.1 g/cm3
• 沸点: 724.3±70.0 °C at 760 mmHg
• 分子式: C₁₉H₁₂FN₃O₆S₂
• 熔点: N/A
• 闪点: 391.9±35.7 °C

AMZ30用途

AMZ30是磷酸酯酶PME-1高效抑制剂,IC50值600nM,选择性降低细胞中去甲基化PP2A。

AMZ30名称

• 中文名: AMZ30
• 英文名: AMZ30

AMZ30生物活性

• 描述: AMZ30是磷酸酯酶PME-1高效抑制剂,IC50值600nM,选择性降低细胞中去甲基化PP2A。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 其他
• 参考文献:

  [1]. Bachovchin DA, et al. Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1. J Med Chem. 2011 Jul 28;54(14):5229-36.

AMZ30物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 724.3±70.0 °C at 760 mmHg
• 分子式: C₁₉H₁₂FN₃O₆S₂
• 分子量: 461.444
• 闪点: 391.9±35.7 °C
• 精确质量: 461.015167
• LogP: 3.58
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.655
• 储存条件: 2-8℃

AMZ30靶点实验

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实验名称：Binding affinity to PME1 assessed as compound-enzyme serine nuclephile adduct formati... 来源：ChEMBL 靶标：Protein phosphatase methylesterase 1 External Id：CHEMBL2212394

实验名称：Irreversible inhibition of PME1 binding to FP-rhodamine in human HEK293T cells at 50 ... 来源：ChEMBL 靶标：Protein phosphatase methylesterase 1 External Id：CHEMBL2212395

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Selectivity ratio of IC50 for acyl peptide hydrolase in human HEK293T cells to IC50 f... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2212396

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：uHTS identification of small molecule modulators of Rev-erb Alpha. 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：SBCCG-A1016-RevErbaLBD-Primary-Assay

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AMZ30英文别名

• (2E)-2-[(4-Fluorophenyl)sulfonyl]-3-{1-[(3-nitrophenyl)sulfonyl]-1H-pyrrol-2-yl}acrylonitrile