N-(4-{5-[3-(Acetylamino)phenyl]-2-(2-Aminopyridin-3-Yl)-3h-Imidazo[4,5-B]pyridin-3-Yl}benzyl)-3-Fluorobenzamide

• 常用名: N-(4-{5-[3-(Acetylamino)phenyl]-2-(2-Aminopyridin-3-Yl)-3h-Imidazo[4,5-B]pyridin-3-Yl}benzyl)-3-Fluorobenzamide
• 英文名: N-(4-{5-[3-(Acetylamino)phenyl]-2-(2-Aminopyridin-3-Yl)-3h-Imidazo[4,5-B]pyridin-3-Yl}benzyl)-3-Fluorobenzamide
• CAS号: 1313880-28-2
• 分子量: 571.6
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₃H₂₆FN₇O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-(4-{5-[3-(Acetylamino)phenyl]-2-(2-Aminopyridin-3-Yl)-3h-Imidazo[4,5-B]pyridin-3-Yl}benzyl)-3-Fluorobenzamide

物理化学性质

• 分子式: C₃₃H₂₆FN₇O₂
• 分子量: 571.6
• InChIKey: WFDHLKUQFQCHKF-UHFFFAOYSA-N
• SMILES: CC(=O)Nc1cccc(-c2ccc3nc(-c4cccnc4N)n(-c4ccc(CNC(=O)c5cccc(F)c5)cc4)c3n2)c1

靶点实验

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实验名称：Experimentally measured binding affinity data (IC50) for protein-ligand complexes der... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-IC50 for protein-ligand complexes

实验名称：Binding affinity to Akt2 (1 to 481) expressed in Sf9 cells assessed as change in melt... 来源：ChEMBL 靶标：RAC-beta serine/threonine-protein kinase External Id：CHEMBL2186221

实验名称：Binding affinity to Akt1 (1 to 480) expressed in Sf9 cells assessed as change in melt... 来源：ChEMBL 靶标：RAC-alpha serine/threonine-protein kinase External Id：CHEMBL2183047

实验名称：Binding affinity to Akt3 (1 to 479) expressed in Sf9 cells assessed as change in melt... 来源：ChEMBL 靶标：RAC-gamma serine/threonine-protein kinase External Id：CHEMBL2186222

实验名称：Antiproliferative activity against human A2780 cells after 72 hrs by MTS assay 来源：ChEMBL 靶标：A2780 External Id：CHEMBL2186219

实验名称：Antiproliferative activity against human AN3CA cells after 72 hrs by MTS assay 来源：ChEMBL 靶标：AN3-CA External Id：CHEMBL2186220

实验名称：Inhibition of Akt3 (1 to 479) expressed in Sf9 cells using biotin-GRPRTSSFAEG as subs... 来源：ChEMBL 靶标：RAC-gamma serine/threonine-protein kinase External Id：CHEMBL2186225

实验名称：Inhibition of Akt1 (1 to 480) expressed in Sf9 cells using biotin-GRPRTSSFAEG as subs... 来源：ChEMBL 靶标：RAC-alpha serine/threonine-protein kinase External Id：CHEMBL2186223

实验名称：Inhibition of Akt2 (1 to 481) expressed in Sf9 cells using biotin-GRPRTSSFAEG as subs... 来源：ChEMBL 靶标：RAC-beta serine/threonine-protein kinase External Id：CHEMBL2186224

实验名称：Inhibition of Akt1 in human A2780 cells assessed as phosphorylation of Akt at S473 af... 来源：ChEMBL 靶标：RAC-alpha serine/threonine-protein kinase External Id：CHEMBL2186213

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