Cyclohexanol, 3-(2-MethyliMidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)-, (1R,3R)

• 常用名: Cyclohexanol, 3-(2-MethyliMidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)-, (1R,3R)
• 英文名: Cyclohexanol, 3-(2-MethyliMidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)-, (1R,3R)
• CAS号: 1315486-05-5
• 分子量: 270.33
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₅H₁₈N₄O
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: Cyclohexanol, 3-(2-MethyliMidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)-, (1R,3R)

物理化学性质

• 分子式: C₁₅H₁₈N₄O
• 分子量: 270.33
• InChIKey: HTMCBXLLCSRXLQ-UHFFFAOYSA-N
• SMILES: Cc1nc2cnc3[nH]ccc3c2n1C1CCCC(O)C1

靶点实验

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实验名称：Thermodynamic solubility of the compound after 24 hrs by LC/UV analysis at pH 2 来源：ChEMBL 靶标：N/A External Id：CHEMBL2162396

实验名称：Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-induced STAT3 pho... 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK1 External Id：CHEMBL2160364

实验名称：Efflux ratio of apparent permeability from basal to apical to apical to basal side of... 来源：ChEMBL 靶标：MDCK External Id：CHEMBL2162397

实验名称：Inhibition of JAK2 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala... 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK2 External Id：CHEMBL2160361

实验名称：Half life in human hepatocytes at 1 uM by LC/MS/MS analysis 来源：ChEMBL 靶标：Hepatocyte External Id：CHEMBL2162394

实验名称：Thermodynamic solubility of the compound after 24 hrs by LC/UV analysis at pH 7.4 来源：ChEMBL 靶标：N/A External Id：CHEMBL2162395

实验名称：Clearance in Sprague-Dawley rat at 0.4 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2162400

实验名称：Selectivity ratio of EC50 for JAK2-mediated STAT5 phosphorylation to EC50 for JAK1-me... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2160367

实验名称：Experimentally measured binding affinity data (Ki) for protein-ligand complexes deriv... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-Ki for protein-ligand complexes

实验名称：Octanol-PBS buffer distribution coefficient, log D of the compound at pH 7.2 at 10 mM... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2160368

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