1-O-十六烷基-2-十二碳六烯酰基-sn-甘油-3-磷酸胆碱

• 常用名: 1-O-十六烷基-2-十二碳六烯酰基-sn-甘油-3-磷酸胆碱
• 英文名: 1-O-HEXADECYL-2-DOCOSAHEXAENOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
• CAS号: 132213-85-5
• 分子量: 792.120
• 密度: N/A
• 沸点: N/A
• 分子式: C₄₆H₈₂NO₇P
• 熔点: N/A
• 闪点: N/A

用途

1-O-十六烷基-2-O-二十二碳六烯酸-sn-甘油-3-磷酸胆碱是尿中存在的内源性代谢产物,可用于肥胖研究[1][2]。

名称

• 中文名: 1-O-十六烷基-2-十二碳六烯酰基-sn-甘油-3-磷酸胆碱
• 英文名: 2-[[(2R)-2-dodeca-4,7,10-trienoyloxy-3-hexadecoxypropoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium

生物活性

• 描述: 1-O-十六烷基-2-O-二十二碳六烯酸-sn-甘油-3-磷酸胆碱是尿中存在的内源性代谢产物,可用于肥胖研究[1][2]。
• 相关类别:
  研究领域 >> 代谢疾病
• 体外研究: 内源性代谢产物被定义为《京都基因和基因组百科全书》注释为我们基因组中约1900种代谢酶的底物或产物。在文献正文中很清楚,许多这些代谢产物都具有毒性[1]。
• 参考文献:

  [1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.

  [2]. Cho K, et al. Combined untargeted and targeted metabolomic profiling reveals urinary biomarkers for discriminating obese from normal-weight adolescents. Pediatr Obes. 2017 Apr;12(2):93-101.

物理化学性质

• 分子式: C₄₆H₈₂NO₇P
• 分子量: 792.120
• 精确质量: 791.582886
• PSA: 103.93000
• LogP: 11.01
• InChIKey: QQQQNYAHSSIZBU-HIQXTUQZSA-N
• SMILES: CCC=CCC=CCC=CCC=CCC=CCC=CCCC(=O)OC(COCCCCCCCCCCCCCCCC)COP(=O)([O-])OCC[N+](C)(C)C

靶点实验

查看更多实验

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

实验名称：qHTS for Inhibitors of binding or entry into cells for Marburg Virus 来源：NCGC 靶标：gene 4 small orf - Marburg virus External Id：VSVM-OFFLINE

实验名称：Discovering small molecule activators of G protein-gated inwardly-rectifying potassiu... 来源：15621 靶标：G protein-activated inward rectifier potassium channel 2 External Id：VANDERBILT_HTS_GIRK2_MPD

实验名称：qHTS for Inhibitors of binding or entry into cells for Lassa Virus 来源：NCGC 靶标：N/A External Id：VSVL-OFFLINE

共6条，当前第1页，共1页

1

英文别名

• (2R)-2-[(4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-Docosahexaenoyloxy]-3-(hexadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate
• C16-22:6 PC
• 1-O-hexadecyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine
• Ethanaminium, 2-[[[(2R)-3-(hexadecyloxy)-2-[[(4Z,7Z,10Z,13Z,16Z,19Z)-1-oxo-4,7,10,13,16,19-docosahexaen-1-yl]oxy]propoxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-, inner salt