ASS234

• 常用名: ASS234
• 英文名: ASS234
• CAS号: 1334106-34-1
• 分子量: 443.624
• 密度: 1.1±0.1 g/cm3
• 沸点: 582.5±45.0 °C at 760 mmHg
• 分子式: C₂₉H₃₇N₃O
• 熔点: N/A
• 闪点: 306.1±28.7 °C

ASS234用途

ASS234(ASS-234)是一种多靶点,强效和CNS可渗透的抑制剂,MAO-1,MAO-B,EeAChE和eqBuChE的IC50分别为5.2,43,350和460 nM；抑制aβ聚集,具有抗氧化特性并在体外保护免受aβ诱导的细胞凋亡；完全阻断aβ1-42和aβ1-40的AChE介导的聚集,显示AChE的双重结合位点；ASS234显着降低aβ1-42介导的SH-SY5Y人神经母细胞瘤细胞的毒性,ASS234是一种有前途的多靶点候选药物,对阿尔茨海默病具有潜在影响。

ASS234名称

• 英文名: ASS234

ASS234生物活性

• 描述: ASS234(ASS-234)是一种多靶点,强效和CNS可渗透的抑制剂,MAO-1,MAO-B,EeAChE和eqBuChE的IC50分别为5.2,43,350和460 nM；抑制aβ聚集,具有抗氧化特性并在体外保护免受aβ诱导的细胞凋亡；完全阻断aβ1-42和aβ1-40的AChE介导的聚集,显示AChE的双重结合位点；ASS234显着降低aβ1-42介导的SH-SY5Y人神经母细胞瘤细胞的毒性,ASS234是一种有前途的多靶点候选药物,对阿尔茨海默病具有潜在影响。
• 参考文献: References 1. Bolea I, et al. J Med Chem. 2011 Dec 22;54(24):8251-70. 2. Bolea I, et al. Curr Alzheimer Res. 2013 Oct;10(8):797-808. 3. del Pino J, et al. CNS Neurosci Ther. 2014 Jun;20(6):568-70. 4. Marco-Contelles J, et al. Front Neurosci. 2016 Jun 28;10:294. View Related Products by Target Monoamine Oxidase (MAO)

ASS234物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 582.5±45.0 °C at 760 mmHg
• 分子式: C₂₉H₃₇N₃O
• 分子量: 443.624
• 闪点: 306.1±28.7 °C
• 精确质量: 443.293671
• LogP: 5.74
• InChIKey: ADCBAOTWERXLAP-UHFFFAOYSA-N
• SMILES: C#CCN(C)Cc1cc2cc(OCCCC3CCN(Cc4ccccc4)CC3)ccc2n1C
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.573

ASS234靶点实验

查看更多实验

实验名称：Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincuba... 来源：ChEMBL 靶标：Acetylcholinesterase External Id：CHEMBL3130754

实验名称：Selectivity ratio of IC50 for human recombinant MAO-B to IC50 for human recombinant M... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3130755

实验名称：Reversible inhibition of rat liver mitochondrial MAO-B using phenylethylamine as subs... 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] B External Id：CHEMBL1931921

实验名称：Irreversible inhibition of rat liver mitochondrial MAO-A using 5-hydroxytriptamine as... 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] A External Id：CHEMBL1931920

实验名称：Inhibition of recombinant human AChE expressed in HEK293 cells preincubated for 15 mi... 来源：ChEMBL 靶标：Acetylcholinesterase External Id：CHEMBL3413435

实验名称：Inhibition of recombinant human BuChE expressed in HEK293 cells preincubated for 15 m... 来源：ChEMBL 靶标：Cholinesterase External Id：CHEMBL3413436

实验名称：Inhibition of human MAO-A expressed in baculovirus infected BTI insect cells preincub... 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] A External Id：CHEMBL3413433

实验名称：Inhibition of human MAO-B expressed in baculovirus infected BTI insect cells preincub... 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] B External Id：CHEMBL3413434

实验名称：Inhibition of human recombinant MAO-B using tyramine as substrate preincubated for 30... 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] B External Id：CHEMBL3129495

实验名称：Inhibition of human recombinant MAO-A using tyramine as substrate preincubated for 30... 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] A External Id：CHEMBL3129496

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ASS234英文别名

• ASS234
• N-({5-[3-(1-Benzyl-4-piperidinyl)propoxy]-1-methyl-1H-indol-2-yl}methyl)-N-methyl-2-propyn-1-amine