Spiro[5H-[1]benzopyrano[2,3-c]pyridine-5,4'(5'H)-oxazol]-2'-amine, 3-(3,6-dihydro-2H-pyran-4-yl)-1-fluoro-7-(2-fluoro-3-pyridinyl)-, (4'S)

• 常用名: Spiro[5H-[1]benzopyrano[2,3-c]pyridine-5,4'(5'H)-oxazol]-2'-amine, 3-(3,6-dihydro-2H-pyran-4-yl)-1-fluoro-7-(2-fluoro-3-pyridinyl)-, (4'S)
• 英文名: Spiro[5H-[1]benzopyrano[2,3-c]pyridine-5,4'(5'H)-oxazol]-2'-amine, 3-(3,6-dihydro-2H-pyran-4-yl)-1-fluoro-7-(2-fluoro-3-pyridinyl)-, (4'S)
• CAS号: 1335497-93-2
• 分子量: 448.4
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₁₈F₂N₄O₃
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: Spiro[5H-[1]benzopyrano[2,3-c]pyridine-5,4'(5'H)-oxazol]-2'-amine, 3-(3,6-dihydro-2H-pyran-4-yl)-1-fluoro-7-(2-fluoro-3-pyridinyl)-, (4'S)

物理化学性质

• 分子式: C₂₄H₁₈F₂N₄O₃
• 分子量: 448.4
• InChIKey: NNDVCBXULMNGBZ-DEOSSOPVSA-N
• SMILES: NC1=NC2(CO1)c1cc(-c3cccnc3F)ccc1Oc1c2cc(C2=CCOCC2)nc1F

靶点实验

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实验名称：Reduction in Abeta40 level in Sprague-Dawley rat brain at 3 mg/kg, po administered as... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3396470

实验名称：Reduction in Abeta40 level in Sprague-Dawley rat CSF assessed as unbound drug level c... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3396468

实验名称：Reduction in Abeta40 level in Sprague-Dawley rat brain assessed as unbound drug level... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3396472

实验名称：Ratio of fEC50 for reduction in orally dosed Abeta40 level in Sprague-Dawley rat brai... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3396473

实验名称：Inhibition of BACE1 in HEK293 cells stably expressing APPSW assessed as reduction in ... 来源：ChEMBL 靶标：Beta-secretase 1 External Id：CHEMBL3396458

实验名称：Intrinsic clearance in rat liver microsomes at 1 uM incubated for for 30 mins in pres... 来源：ChEMBL 靶标：Liver microsome External Id：CHEMBL3396459

实验名称：Inhibition of human recombinant BACE1 pre-incubated with enzyme for 60 mins before fl... 来源：ChEMBL 靶标：Beta-secretase 1 External Id：CHEMBL3396457

实验名称：Efflux ratio in pig LLC-PK1 cells expressing human MDR1 gene at 5 uM after 2 hrs by L... 来源：ChEMBL 靶标：LLC-PK1 External Id：CHEMBL3396462

实验名称：Efflux ratio in pig LLC-PK1 cells expressing rat mdr1a gene at 5 uM after 2 hrs by LC... 来源：ChEMBL 靶标：LLC-PK1 External Id：CHEMBL3396463

实验名称：Intrinsic clearance in human liver microsomes at 1 uM incubated for for 30 mins in pr... 来源：ChEMBL 靶标：Liver microsome External Id：CHEMBL3396460

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