4-[[4-[(2-Amino-3-pyridinyl)carbonyl]-1-piperazinyl]methyl]-N-[4-(2-phenylethynyl)phenyl]benzamide

• 常用名: 4-[[4-[(2-Amino-3-pyridinyl)carbonyl]-1-piperazinyl]methyl]-N-[4-(2-phenylethynyl)phenyl]benzamide
• 英文名: 4-[[4-[(2-Amino-3-pyridinyl)carbonyl]-1-piperazinyl]methyl]-N-[4-(2-phenylethynyl)phenyl]benzamide
• CAS号: 1338216-98-0
• 分子量: 515.6
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₂H₂₉N₅O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 4-[[4-[(2-Amino-3-pyridinyl)carbonyl]-1-piperazinyl]methyl]-N-[4-(2-phenylethynyl)phenyl]benzamide

物理化学性质

• 分子式: C₃₂H₂₉N₅O₂
• 分子量: 515.6
• InChIKey: YPMOWWPVPPPBET-UHFFFAOYSA-N
• SMILES: Nc1ncccc1C(=O)N1CCN(Cc2ccc(C(=O)Nc3ccc(C#Cc4ccccc4)cc3)cc2)CC1

靶点实验

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实验名称：Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-dri... 来源：ChEMBL 靶标：Endothelial PAS domain-containing protein 1 External Id：CHEMBL3380585

实验名称：Suppression of HIF1alpha protein expression in BALB/cA mouse xenografted with human U... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3380586

实验名称：Suppression of HIF1alpha mRNA expression in BALB/cA mouse xenografted with human U251... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3380587

实验名称：Suppression of HIF1alpha protein expression in BALB/cA mouse xenografted with human U... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3380592

实验名称：Toxicity in BALB/cA mouse xenografted with human U251 cells assessed as mouse surviva... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3380593

实验名称：Antitumor activity against human U251 cells xenografted in BALB/cA mouse assessed as ... 来源：ChEMBL 靶标：U-251 External Id：CHEMBL3380590

实验名称：Toxicity in BALB/cA mouse xenografted with human U251 cells assessed as reduction in ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3380591

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