环氧酶素

更新时间：2024-01-13 20:36:13

环氧酶素结构式	常用名	环氧酶素	英文名	Epoxomicin
	CAS号	134381-21-8	分子量	554.719
	密度	1.1±0.1 g/cm3	沸点	795.7±60.0 °C at 760 mmHg
	分子式	C₂₈H₅₀N₄O₇	熔点	107-109ºC
	MSDS	中文版美版	闪点	435.0±32.9 °C

环氧酶素用途

Epoxomicin(BU-4061T)是从放线菌中分离出的抗肿瘤化合物，是20S蛋白酶体的选择不可逆抑制剂。

中文名	N-乙酰基-N-甲基-L-异亮氨酰-L-异亮氨酰-N-[(1S)-3-甲基-1-[[(2R)-2-甲基-2-环氧乙烷基]羰基]丁基]-L-苏氨酰胺
英文名	Epoxomicin
英文别名	更多

描述	Epoxomicin是一种可渗透细胞且不可逆的蛋白酶体抑制剂,主要抑制胰凝乳蛋白酶样活性。
相关类别	信号通路 >> 代谢酶/蛋白酶 >> 蛋白酶体研究领域 >> 癌症天然产物 >> 其他
参考文献	[1]. Kim KB, et al. Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: insights into specificity and potency. Bioorg Med Chem Lett. 1999 Dec 6;9(23):3335-40. [2]. Hanada M, et al. Epoxomicin, a new antitumor agent of microbial origin. J Antibiot (Tokyo). 1992 Nov;45(11):1746-52. [3]. Garrett IR, et al. Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro. J Clin Invest. 2003 Jun;111(11):1771-82. [4]. McNaught KS, et al. Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease. Ann Neurol. 2004 Jul;56(1):149-62. [5]. Rideout HJ, et al. Dopaminergic neurons in rat ventral midbrain cultures undergo selective apoptosis and form inclusions, but do not up-regulate iHSP70, following proteasomal inhibition. J Neurochem. 2005 Jun;93(5):1304-13.

描述

Epoxomicin是一种可渗透细胞且不可逆的蛋白酶体抑制剂,主要抑制胰凝乳蛋白酶样活性。

相关类别

信号通路 >> 代谢酶/蛋白酶 >> 蛋白酶体

研究领域 >> 癌症

天然产物 >> 其他

参考文献

[1]. Kim KB, et al. Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: insights into specificity and potency. Bioorg Med Chem Lett. 1999 Dec 6;9(23):3335-40.

[2]. Hanada M, et al. Epoxomicin, a new antitumor agent of microbial origin. J Antibiot (Tokyo). 1992 Nov;45(11):1746-52.

[3]. Garrett IR, et al. Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro. J Clin Invest. 2003 Jun;111(11):1771-82.

[4]. McNaught KS, et al. Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease. Ann Neurol. 2004 Jul;56(1):149-62.

[5]. Rideout HJ, et al. Dopaminergic neurons in rat ventral midbrain cultures undergo selective apoptosis and form inclusions, but do not up-regulate iHSP70, following proteasomal inhibition. J Neurochem. 2005 Jun;93(5):1304-13.

密度	1.1±0.1 g/cm3
沸点	795.7±60.0 °C at 760 mmHg
熔点	107-109ºC
分子式	C₂₈H₅₀N₄O₇
分子量	554.719
闪点	435.0±32.9 °C
精确质量	554.367920
PSA	157.44000
LogP	3.32
外观性状	白色至灰白色固体
蒸汽压	0.0±6.3 mmHg at 25°C
折射率	1.504
储存条件	-20°C

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport

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S7038,BU-4061T

Epoxomicin (BU-4061T)

(2S,3S)-2-[[(2S,3S)-2-[acetyl(methyl)amino]-3-methylpentanoyl]amino]-N-[(2S,3R)-3-hydroxy-2-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]butanoyl]-3-methylpentanamide

Epoxomicin

N-Acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-{(2S)-4-methyl-1-[(2R)-2-methyl-2-oxiranyl]-1-oxo-2-pentanyl}-L-threoninamide

L-Threoninamide, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-