ML154

• 常用名: ML154
• 英文名: ML154
• CAS号: 1345964-89-7
• 分子量: 261.29600
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₂₆BrN₂PS
• 熔点: N/A
• 闪点: N/A

ML154用途

ML154是一种有效的NPSR拮抗剂。ML154具有研究焦虑、成瘾和食物障碍的潜力[1]。

ML154名称

• 中文名: ML 154,神经肽S受体拮抗剂
• 英文名: 1-cinnamyl-3-(diphenylphosphorothioyl)-2-methylimidazo[1,2-a]pyridin-1-ium bromide

ML154生物活性

• 描述: ML154是一种有效的NPSR拮抗剂。ML154具有研究焦虑、成瘾和食物障碍的潜力[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 靶点实验:

  NPSR[1]

• 参考文献:

  [1]. Batran RZ, et al. New quinolone derivatives as neuropeptide S receptor antagonists: Design, synthesis, homology modeling, dynamic simulations and modulation of Gq/Gs signaling pathways. Bioorg Chem. 2021;111:104817.

ML154物理化学性质

• 分子式: C₂₉H₂₆BrN₂PS
• 分子量: 261.29600
• 精确质量: 261.04600
• PSA: 87.66000
• LogP: 2.61550
• 储存条件: -20°C

ML154靶点实验

查看更多实验

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL5062802

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Counterscreen for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1): Lum... 来源：The Scripps Research Institute Molecular Screening Center 靶标：transactivating tegument protein VP16 [Human herpesvirus 1] External Id：VP16_INH_LUMI_1536_3X%INH CSRUN for SRC1

实验名称：Thermal Shift Assay. Domain: start/stop: G861-E979 来源：ChEMBL 靶标：Transcription intermediary factor 1-alpha External Id：CHEMBL5068409

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Luminescence-based cell-based high throughput confirmation assay for inhibitors of th... 来源：The Scripps Research Institute Molecular Screening Center 靶标：nuclear receptor coactivator 1 isoform 1 [Homo sapiens] External Id：SRC1_INH_LUMI_1536_3X%INH CRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：PDSP Secondary Binding target: ADRA2A - Compounds are tested at 10 uM concentration, ... 来源：ChEMBL 靶标：Alpha-2A adrenergic receptor External Id：CHEMBL5442194

实验名称：PDSP Secondary Binding target: OPRM1 - Compounds are tested at 10 uM concentration, p... 来源：ChEMBL 靶标：Mu-type opioid receptor External Id：CHEMBL5442190

实验名称：PDSP Secondary Binding target: ADRB3 - Compounds are tested at 10 uM concentration, p... 来源：ChEMBL 靶标：Beta-3 adrenergic receptor External Id：CHEMBL5442189

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ML154英文别名

• aeg 3482
• NCGC00185684