OSU-2S

• 常用名: OSU-2S
• 英文名: OSU-2S
• CAS号: 1351056-65-9
• 分子量: 335.532
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₃₇NO₂
• 熔点: N/A
• 闪点: N/A

OSU-2S用途

非免疫抑制性FTY720类似物,PKCδ激活剂具有较高的抗增殖效力,Huh7,Hep3B和PLC5细胞的IC50分别为2.4,2.4和3.5 uM；相对于FTY720对HCC细胞表现出较高的体外抗增殖功效。在正常肝细胞中没有细胞毒性,虽然缺乏S1P1受体活性；但通过HCC肿瘤细胞中ROS依赖性PKCδ活化诱导胱天蛋白酶依赖性细胞凋亡。

OSU-2S名称

• 英文名: OSU-2S

OSU-2S生物活性

• 描述: 非免疫抑制性FTY720类似物,PKCδ激活剂具有较高的抗增殖效力,Huh7,Hep3B和PLC5细胞的IC50分别为2.4,2.4和3.5 uM；相对于FTY720对HCC细胞表现出较高的体外抗增殖功效。在正常肝细胞中没有细胞毒性,虽然缺乏S1P1受体活性；但通过HCC肿瘤细胞中ROS依赖性PKCδ活化诱导胱天蛋白酶依赖性细胞凋亡。
• 参考文献: References 1. Omar HA, et al. Hepatology. 2011 Jun;53(6):1943-58. 2. Mani R, et al. Leukemia. 2015 Feb;29(2):346-55. 3. Mani R, et al. Exp Hematol. 2015 Sep;43(9):770-4.e2. 4. Omar HA, et al. Front Pharmacol. 2016 Nov 30;7:463. eCollection 2016. View Related Products by Target PKC

OSU-2S物理化学性质

• 分子式: C₂₁H₃₇NO₂
• 分子量: 335.532
• InChIKey: MDUCYXCGWGNEMH-NRFANRHFSA-N
• SMILES: CCCC(N)(CO)CCc1ccc(OCCCCCC(C)C)cc1

OSU-2S靶点实验

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实验名称：Inhibition of Akt Thr408 phosphorylation in human HepG2 cells at 10 uM after 48 hrs b... 来源：ChEMBL 靶标：RAC-alpha serine/threonine-protein kinase External Id：CHEMBL4133414

实验名称：Inhibition of Akt Thr408 phosphorylation in human Hep3B cells at 10 uM after 48 hrs b... 来源：ChEMBL 靶标：RAC-alpha serine/threonine-protein kinase External Id：CHEMBL4133415

实验名称：Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4133392

实验名称：Cytotoxicity against human Hep3B cells after 48 hrs by MTT assay 来源：ChEMBL 靶标：Hep 3B2 External Id：CHEMBL4133393

实验名称：Inhibition of ERK1/2 phosphorylation in human HepG2 cells at 10 uM after 48 hrs by We... 来源：ChEMBL 靶标：Mitogen-activated protein kinase 3 External Id：CHEMBL4133400

实验名称：Induction of PKCdelta cleavage in human Hep3B cells at 10 uM after 48 hrs by Western ... 来源：ChEMBL 靶标：Protein kinase C delta type External Id：CHEMBL4133401

实验名称：Induction of PKCdelta cleavage in human HepG2 cells at 10 uM after 48 hrs by Western ... 来源：ChEMBL 靶标：Protein kinase C delta type External Id：CHEMBL4133398

实验名称：Inhibition of Akt Ser473 phosphorylation in human HepG2 cells at 10 uM after 48 hrs b... 来源：ChEMBL 靶标：RAC-alpha serine/threonine-protein kinase External Id：CHEMBL4133399

实验名称：Cytotoxicity against human F180 cells after 48 hrs by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL4133396

实验名称：Induction of apoptosis in human Hep3B cells assessed as increase in caspase3/7 activi... 来源：ChEMBL 靶标：Hep 3B2 External Id：CHEMBL4133397

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