(S)-(3-((6-(6-Methoxy-5-methylpyridin-3-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)oxy)pyrrolidin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone

• 常用名: (S)-(3-((6-(6-Methoxy-5-methylpyridin-3-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)oxy)pyrrolidin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone
• 英文名: (S)-(3-((6-(6-Methoxy-5-methylpyridin-3-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)oxy)pyrrolidin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone
• CAS号: 1354689-60-3
• 分子量: 453.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₃₁N₅O₄
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: (S)-(3-((6-(6-Methoxy-5-methylpyridin-3-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)oxy)pyrrolidin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone

物理化学性质

• 分子式: C₂₄H₃₁N₅O₄
• 分子量: 453.5
• InChIKey: VHBAXDNZLJTAHW-IBGZPJMESA-N
• SMILES: COc1ncc(N2CCc3ncnc(OC4CCN(C(=O)C5CCOCC5)C4)c3C2)cc1C

靶点实验

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实验名称：Inhibition of PI3Kdelta in 50% rat blood assessed as reduction in anti-IgM stimulated... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4134216

实验名称：Inhibition of recombinant human myristoylated PI3Kdelta catalytic domain expressed in... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform External Id：CHEMBL4134214

实验名称：Inhibition of PI3Kdelta in Balb/c mouse splenocytes assessed as reduction in anti-IgM... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform External Id：CHEMBL4134215

实验名称：Inhibition of recombinant human myristoylated PI3Kalpha catalytic domain expressed in... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform External Id：CHEMBL4134212

实验名称：Inhibition of recombinant human myristoylated PI3Kbeta catalytic domain expressed in ... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform External Id：CHEMBL4134213

实验名称：Inhibition of PI3Kgamma (unknown origin) using phosphatidyl inositol as substrate mea... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform External Id：CHEMBL4134210

实验名称：Inhibition of PI3Kdelta (unknown origin) using phosphatidyl inositol as substrate mea... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform External Id：CHEMBL4134211

实验名称：Lipophilicity, log P of the compound by artificial membrane based assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL4134288

实验名称：Intrinsic clearance in rat liver microsomes assessed per mg protein 来源：ChEMBL 靶标：N/A External Id：CHEMBL4134289

实验名称：Effective permeability of the compound by PAMPA 来源：ChEMBL 靶标：N/A External Id：CHEMBL4134287

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