JWH-424

• 常用名: JWH-424
• 英文名: JWH-424
• CAS号: 1366068-04-3
• 分子量: 420.342
• 密度: 1.3±0.1 g/cm3
• 沸点: 572.4±25.0 °C at 760 mmHg
• 分子式: C₂₄H₂₂BrNO
• 熔点: N/A
• 闪点: 300.0±23.2 °C

JWH-424用途

JWH 018 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 9.0 and 2.94 nM, respectively). This cannabimimetic compound has frequently been found in herbal blends. JWH 424 is an 8-bromonaphthyl derivative of JWH 018 which shows a reduced selectivity for CB1 over CB2 (Ki = 20.9 and 5.4 nM, respectively).

JWH-424名称

• 英文名: (8-bromonaphthalen-1-yl)-(1-pentylindol-3-yl)methanone

JWH-424物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 572.4±25.0 °C at 760 mmHg
• 分子式: C₂₄H₂₂BrNO
• 分子量: 420.342
• 闪点: 300.0±23.2 °C
• 精确质量: 419.088470
• PSA: 22.00000
• LogP: 7.63
• InChIKey: QXZYVJRMQVOOEQ-UHFFFAOYSA-N
• SMILES: CCCCCn1cc(C(=O)c2cccc3cccc(Br)c23)c2ccccc21
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.628

JWH-424靶点实验

查看更多实验

实验名称：Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL2210669

实验名称：Induction of catalepsy in iv dosed Harlan ICR mouse at 40 mins measured for 5 mins by... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2213562

实验名称：Hypothermic activity in iv dosed Harlan ICR mouse assessed as change in rectal temper... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2211106

实验名称：Antinociceptive activity in iv dosed Harlan ICR mouse assessed as latency to heat-ind... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2211096

实验名称：Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr... 来源：ChEMBL 靶标：Cannabinoid receptor 2 External Id：CHEMBL2210670

实验名称：Selectivity ratio of Ki for human CB1 receptor to Ki for human CB2 receptor 来源：ChEMBL 靶标：N/A External Id：CHEMBL2210671

实验名称：Locomotor activity in iv dosed Harlan ICR mouse from 5 to 15 mins by spontaneous loco... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2210676

共7条，当前第1页，共1页

1

JWH-424英文别名

• JWH-424
• (8-Bromo-1-naphthyl)(1-pentyl-1H-indol-3-yl)methanone