(1R,2S)-N-(5-chloropyridin-2-yl)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-phenylcyclopropanecarboxamide

• 常用名: (1R,2S)-N-(5-chloropyridin-2-yl)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-phenylcyclopropanecarboxamide
• 英文名: (1R,2S)-N-(5-chloropyridin-2-yl)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-phenylcyclopropanecarboxamide
• CAS号: 1369763-19-8
• 分子量: 408.9
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₁ClN₄O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: (1R,2S)-N-(5-chloropyridin-2-yl)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-phenylcyclopropanecarboxamide

物理化学性质

• 分子式: C₂₂H₂₁ClN₄O₂
• 分子量: 408.9
• InChIKey: ALURJXGAMCOREI-PGRDOPGGSA-N
• SMILES: CC1=NC(=NC=C1OC[C@]2(C[C@H]2C(=O)NC3=NC=C(C=C3)Cl)C4=CC=CC=C4)C

靶点实验

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实验名称：Binding affinity to human OX1R by radioligand displacement binding assay 来源：ChEMBL 靶标：Orexin/Hypocretin receptor type 1 External Id：CHEMBL3588583

实验名称：Sleep promoting activity in C57BL/6NCrlCrlj mouse assessed as reduction in wakefulnes... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3588599

实验名称：Binding affinity to human OX2R by radioligand displacement binding assay 来源：ChEMBL 靶标：Orexin receptor type 2 External Id：CHEMBL3588582

实验名称：Activity at P-gp (unknown origin) assessed as corrected flux ratio 来源：ChEMBL 靶标：N/A External Id：CHEMBL3588588

实验名称：Time dependent inhibition of CYP3A in human liver microsomes assessed as enzyme activ... 来源：ChEMBL 靶标：Cytochrome P450 3A7 External Id：CHEMBL3588586

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