(1R,2S)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)-2-(((4-(methoxymethyl)-2-methylpyrimidin-5-yl)oxy)methyl)cyclopropanecarboxamide

• 常用名: (1R,2S)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)-2-(((4-(methoxymethyl)-2-methylpyrimidin-5-yl)oxy)methyl)cyclopropanecarboxamide
• 英文名: (1R,2S)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)-2-(((4-(methoxymethyl)-2-methylpyrimidin-5-yl)oxy)methyl)cyclopropanecarboxamide
• CAS号: 1369764-98-6
• 分子量: 440.4
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₂₂F₂N₄O₃
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: (1R,2S)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)-2-(((4-(methoxymethyl)-2-methylpyrimidin-5-yl)oxy)methyl)cyclopropanecarboxamide

物理化学性质

• 分子式: C₂₃H₂₂F₂N₄O₃
• 分子量: 440.4
• InChIKey: WRPGNWQVJUWOTB-FDDCHVKYSA-N
• SMILES: CC1=NC=C(C(=N1)COC)OC[C@]2(C[C@H]2C(=O)NC3=NC=C(C=C3)F)C4=CC(=CC=C4)F

靶点实验

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实验名称：Drug uptake in P-gp-knockout rat thalamus at 78.7 to 189.8 MBq, iv after 90 mins by P... 来源：ChEMBL 靶标：Thalamus External Id：CHEMBL2428718

实验名称：Drug uptake in P-gp-knockout rat cerebellum at 78.7 to 189.8 MBq, iv after 90 mins by... 来源：ChEMBL 靶标：Cerebellum External Id：CHEMBL2428717

实验名称：Antagonist activity at cannabinoid CB1 receptor (unknown origin) expressed in HEK 293... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL2428732

实验名称：Antagonist activity at melatonin MT1A receptor (unknown origin) expressed in HEK 293 ... 来源：ChEMBL 靶标：Melatonin receptor type 1A External Id：CHEMBL2428731

实验名称：Ratio of flux ratio in pig LLC cells expressing MDR1 to flux ratio on pig LLC-PK1 cel... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2428722

实验名称：Flux ratio of permeability from apical to basolateral to basolateral to apical side i... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2428736

实验名称：Octanol-phosphate buffer partition coefficient, log D of the compound at pH 7.4 by Sh... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2428735

实验名称：Flux ratio of permeability from apical to basolateral to basolateral to apical side i... 来源：ChEMBL 靶标：LLC-PK1 External Id：CHEMBL2428723

实验名称：Drug uptake in P-gp-knockout rat neocortex at 78.7 to 189.8 MBq, iv after 90 mins by ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2428730

实验名称：Drug uptake in P-gp-knockout rat hippocampus at 78.7 to 189.8 MBq, iv after 90 mins b... 来源：ChEMBL 靶标：Hippocampus External Id：CHEMBL2428729

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