EZH2-IN-3

• 常用名: EZH2-IN-3
• 英文名: EZH2-IN-3
• CAS号: 1377997-28-8
• 分子量: 489.996
• 密度: 1.3±0.1 g/cm3
• 沸点: 666.4±55.0 °C at 760 mmHg
• 分子式: C₂₇H₂₈ClN₅O₂
• 熔点: N/A
• 闪点: 356.8±31.5 °C

EZH2-IN-3用途

EZH2-IN-3是EZH2和EZH1的高选择性小分子抑制剂,wt EZH2/EZH2 Y641N/wt EZH1的IC50分别为21/197/213 nM；抑制全局组蛋白H3赖氨酸27甲基化并引起选择性增殖缺陷。

EZH2-IN-3名称

• 英文名: 3-Chloro-4-[2-cyano-3-(4-pyridazinyl)phenoxy]-N-(2,2,6,6-tetramethyl-4-piperidinyl)benzamide

EZH2-IN-3生物活性

• 描述: EZH2-IN-3是EZH2和EZH1的高选择性小分子抑制剂,wt EZH2/EZH2 Y641N/wt EZH1的IC50分别为21/197/213 nM；抑制全局组蛋白H3赖氨酸27甲基化并引起选择性增殖缺陷。
• 参考文献: References 1. Garapaty-Rao S, et al. Chem Biol. 2013 Nov 21;20(11):1329-39. View Related Products by Target Histone Methyltransferase (HMTase)

EZH2-IN-3物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 666.4±55.0 °C at 760 mmHg
• 分子式: C₂₇H₂₈ClN₅O₂
• 分子量: 489.996
• 闪点: 356.8±31.5 °C
• 精确质量: 489.193146
• LogP: 4.63
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.631

EZH2-IN-3靶点实验

查看更多实验

实验名称：Inhibition of wild type EZH2 (unknown origin) 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EZH2 External Id：CHEMBL3271451

实验名称：Passive permeability from apical to basolateral side in human Caco2 cells 来源：ChEMBL 靶标：Caco-2 External Id：CHEMBL3271453

实验名称：Inhibition of EZH2 (unknown origin) 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EZH2 External Id：CHEMBL5138242

实验名称：Inhibition of EZH2 Y641N mutant (unknown origin) 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EZH2 External Id：CHEMBL3271452

实验名称：Efflux ratio of passive permeability in human Caco2 cells 来源：ChEMBL 靶标：Caco-2 External Id：CHEMBL3271455

实验名称：Passive permeability from basolateral to apical side in human Caco2 cells 来源：ChEMBL 靶标：Caco-2 External Id：CHEMBL3271454

实验名称：Inhibition of EZH2 (unknown origin) using biotinylated nucleosome, H3K27me3 activator... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EZH2 External Id：CHEMBL3607425

实验名称：Inhibition of wild-type EZH2 (unknown origin) 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EZH2 External Id：CHEMBL5123936

实验名称：Inhibition of EZH2 in human KARPAS422 cells assessed as global reduction in H3K27me3 ... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EZH2 External Id：CHEMBL3271462

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EZH2-IN-3英文别名

• 3-Chloro-4-[2-cyano-3-(4-pyridazinyl)phenoxy]-N-(2,2,6,6-tetramethyl-4-piperidinyl)benzamide