3-{6-[(4r)-6-Azaspiro[2.5]oct-4-Yloxy]pyrazin-2-Yl}-5-(2,6-Difluorophenyl)-1h-Indazole

• 常用名: 3-{6-[(4r)-6-Azaspiro[2.5]oct-4-Yloxy]pyrazin-2-Yl}-5-(2,6-Difluorophenyl)-1h-Indazole
• 英文名: 3-{6-[(4r)-6-Azaspiro[2.5]oct-4-Yloxy]pyrazin-2-Yl}-5-(2,6-Difluorophenyl)-1h-Indazole
• CAS号: 1380915-95-6
• 分子量: 433.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₁F₂N₅O
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 3-{6-[(4r)-6-Azaspiro[2.5]oct-4-Yloxy]pyrazin-2-Yl}-5-(2,6-Difluorophenyl)-1h-Indazole

物理化学性质

• 分子式: C₂₄H₂₁F₂N₅O
• 分子量: 433.5
• InChIKey: FCGLYPSBPNFQRF-FQEVSTJZSA-N
• SMILES: Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(OC4CNCCC45CC5)n3)c2c1

靶点实验

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实验名称：Inhibition of pan Pim in human KMS-12-BM cells assessed as phosphorylation of biotiny... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3396422

实验名称：Intrinsic clearance in rat liver microsomes assessed as compound remaining at 1 uM af... 来源：ChEMBL 靶标：Liver microsome External Id：CHEMBL3396423

实验名称：Inhibition of full length recombinant Pim-2 (unknown origin) assessed as phosphorylat... 来源：ChEMBL 靶标：Serine/threonine-protein kinase pim-2 External Id：CHEMBL3396420

实验名称：Inhibition of full length recombinant Pim-3 (unknown origin) assessed as phosphorylat... 来源：ChEMBL 靶标：Serine/threonine-protein kinase pim-3 External Id：CHEMBL3396421

实验名称：Half life in Sprague-Dawley rat at 2 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3396426

实验名称：AUC in Sprague-Dawley rat at 5 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3396427

实验名称：Clearance in Sprague-Dawley rat at 2 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3396424

实验名称：Volume of distribution at steady state in Sprague-Dawley rat at 2 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3396425

实验名称：Competitive binding affinity at CAMK4 (unknown origin) at 1 uM relative to control 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type IV External Id：CHEMBL3396430

实验名称：Competitive binding affinity at CLK2 (unknown origin) at 1 uM relative to control 来源：ChEMBL 靶标：Dual specificity protein kinase CLK2 External Id：CHEMBL3396431

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