2-Pyridinecarboxamide, N-[3-[(6R)-8-amino-3-cyano-5,6-dihydro-6-methylimidazo[1,2-a]pyrazin-6-yl]-4-fluorophenyl]-5-cyano

• 常用名: 2-Pyridinecarboxamide, N-[3-[(6R)-8-amino-3-cyano-5,6-dihydro-6-methylimidazo[1,2-a]pyrazin-6-yl]-4-fluorophenyl]-5-cyano
• 英文名: 2-Pyridinecarboxamide, N-[3-[(6R)-8-amino-3-cyano-5,6-dihydro-6-methylimidazo[1,2-a]pyrazin-6-yl]-4-fluorophenyl]-5-cyano
• CAS号: 1383741-90-9
• 分子量: 414.4
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₁₅FN₈O
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 2-Pyridinecarboxamide, N-[3-[(6R)-8-amino-3-cyano-5,6-dihydro-6-methylimidazo[1,2-a]pyrazin-6-yl]-4-fluorophenyl]-5-cyano

物理化学性质

• 分子式: C₂₁H₁₅FN₈O
• 分子量: 414.4
• InChIKey: PEYUKFMDCGZLQN-NRFANRHFSA-N
• SMILES: CC1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cn2c(C#N)cnc2C(N)=N1

靶点实验

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实验名称：Inhibition of human CYP3A4 using midazolam as substrate by fluorescence plate reader ... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL5041779

实验名称：Free drug concentration in mouse plasma measured after 4.5 hrs by HPLC-MS/MS method 来源：ChEMBL 靶标：N/A External Id：CHEMBL5041736

实验名称：Free drug concentration in human plasma measured after 4.5 hrs by HPLC-MS/MS method 来源：ChEMBL 靶标：N/A External Id：CHEMBL5041735

实验名称：Free drug concentration in rat brain measured after 5 hrs by HPLC-MS/MS method 来源：ChEMBL 靶标：N/A External Id：CHEMBL5041734

实验名称：Metabolic stability in dog liver microsomes assessed as metabolite formation after 15... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5041733

实验名称：Inhibition of human CYP3A4 by fluorescence plate reader analysis 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL5041739

实验名称：Free drug concentration in dog plasma measured after 4.5 hrs by HPLC-MS/MS method 来源：ChEMBL 靶标：N/A External Id：CHEMBL5041737

实验名称：Inhibition of hERG expressed in HEK293 cells at -80 mV holding potential by automated... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL5041728

实验名称：Ratio of apparent permeability across apical to basolateral side in the presence of P... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5041727

实验名称：Apparent permeability across apical to basolateral side in dog MDCK-MDR1 cells at 5 u... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5041726

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