2-PMDQ

• 常用名: 2-PMDQ
• 英文名: 2-PMDQ
• CAS号: 139047-55-5
• 分子量: 361.44
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₃N₅O
• 熔点: N/A
• 闪点: N/A

2-PMDQ用途

AT-112 是一种酮坦色林类似物。AT-112 具有血液动力学作用。AT-112显著降低门静脉分支血流量和门静脉压力。AT-112 可用于门脉高压高动力循环发病机制的研究。

2-PMDQ名称

• 英文名: at 112

2-PMDQ生物活性

• 描述: AT-112 是一种酮坦色林类似物。AT-112 具有血液动力学作用。AT-112显著降低门静脉分支血流量和门静脉压力。AT-112 可用于门脉高压高动力循环发病机制的研究。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Lin HC, et al The hemodynamic effects of AT-112, an analog of ketanserin, in portal hypertensive rats. Pharmacology. 1997 Jan;54(1):16-23.

2-PMDQ物理化学性质

• 分子式: C₂₁H₂₃N₅O
• 分子量: 361.44
• 精确质量: 361.19000
• PSA: 56.63000
• LogP: 0.87320
• InChIKey: ALPFEYWIGFAARN-UHFFFAOYSA-N
• SMILES: O=c1nc2ccccc2c2n1CC(CN1CCN(c3ccccc3)CC1)N2

2-PMDQ靶点实验

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实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primar... 来源：NCGC 靶标：67.9K protein [Vaccinia virus] External Id：Vaccinia-p2mCherry

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

实验名称：qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary ... 来源：NCGC 靶标：67.9K protein [Vaccinia virus] External Id：Vaccinia-p2Venus

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Blood pressure lowering activity in spontaneously hypertensive rats (SHR) after 1 hou... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL791381

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2-PMDQ英文别名

• [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P