Imidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one, 6-(2-chloro-6-fluorophenyl)-2-[(1,2,3,4-tetrahydro-2,4,4-trimethyl-7-isoquinolinyl)amino]

• 常用名: Imidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one, 6-(2-chloro-6-fluorophenyl)-2-[(1,2,3,4-tetrahydro-2,4,4-trimethyl-7-isoquinolinyl)amino]
• 英文名: Imidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one, 6-(2-chloro-6-fluorophenyl)-2-[(1,2,3,4-tetrahydro-2,4,4-trimethyl-7-isoquinolinyl)amino]
• CAS号: 1395028-22-4
• 分子量: 504.0
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₃ClFN₇O
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: Imidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one, 6-(2-chloro-6-fluorophenyl)-2-[(1,2,3,4-tetrahydro-2,4,4-trimethyl-7-isoquinolinyl)amino]

物理化学性质

• 分子式: C₂₆H₂₃ClFN₇O
• 分子量: 504.0
• InChIKey: LZNRTNXWTSKNMC-UHFFFAOYSA-N
• SMILES: CN1Cc2cc(Nc3ncc4c(=O)n(-c5c(F)cccc5Cl)c5nccn5c4n3)ccc2C(C)(C)C1

靶点实验

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实验名称：In vivo inhibition of Wee1 in human NCI-H1299 cells xenografted in mouse assessed as ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3374859

实验名称：Antiproliferative activity against human NCI-H1299 cells after 72 hrs by cell titer g... 来源：ChEMBL 靶标：NCI-H1299 External Id：CHEMBL4388514

实验名称：Binding affinity to wild type N-terminal GST-tagged human WEE1 catalytic domain (215 ... 来源：ChEMBL 靶标：Wee1-like protein kinase External Id：CHEMBL4388515

实验名称：Inhibition of WEE1 in human NCI-H1299 cells assessed as reduction in Cdc2 phosphoryla... 来源：ChEMBL 靶标：Wee1-like protein kinase External Id：CHEMBL4388516

实验名称：Clearance in mouse microsomes 来源：ChEMBL 靶标：N/A External Id：CHEMBL4388517

实验名称：Clearance in CD-1 mouse at 3 mg/kg, iv 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3372988

实验名称：Half life in CD-1 mouse at 3 mg/kg, iv 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3372987

实验名称：Oral bioavailability in CD-1 mouse at 10 mg/kg 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3372990

实验名称：AUC in CD-1 mouse at 10 mg/kg, po 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3372989

实验名称：Antitumor activity against human NCI-H1299 cells xenografted in mouse assessed as dep... 来源：ChEMBL 靶标：NCI-H1299 External Id：CHEMBL3374850

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