2-Oxazolamine, 4-[4-(difluoromethoxy)phenyl]-4-[3-(2-fluoro-3-pyridinyl)phenyl]-4,5-dihydro-, (4R)

• 常用名: 2-Oxazolamine, 4-[4-(difluoromethoxy)phenyl]-4-[3-(2-fluoro-3-pyridinyl)phenyl]-4,5-dihydro-, (4R)
• 英文名: 2-Oxazolamine, 4-[4-(difluoromethoxy)phenyl]-4-[3-(2-fluoro-3-pyridinyl)phenyl]-4,5-dihydro-, (4R)
• CAS号: 1398519-62-4
• 分子量: 399.4
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₁₆F₃N₃O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 2-Oxazolamine, 4-[4-(difluoromethoxy)phenyl]-4-[3-(2-fluoro-3-pyridinyl)phenyl]-4,5-dihydro-, (4R)

物理化学性质

• 分子式: C₂₁H₁₆F₃N₃O₂
• 分子量: 399.4
• InChIKey: ZRSKBWQUUIETSK-OAQYLSRUSA-N
• SMILES: NC1=NC(c2ccc(OC(F)F)cc2)(c2cccc(-c3cccnc3F)c2)CO1

靶点实验

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实验名称：Clearance in rat liver microsomes assessed per mg of protein at 1 uM after 30 mins by... 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL2183106

实验名称：Clearance in human liver microsomes assessed per mg of protein at 1 uM after 30 mins ... 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL2183107

实验名称：Efflux ratio of permeability from basal to apical to apical to basal side of pig LLC-... 来源：ChEMBL 靶标：LLC-PK1 External Id：CHEMBL2183104

实验名称：Apparent permeability across pig LLC-PK1 cells at 5 uM after 2 hrs by LC/MS analysis 来源：ChEMBL 靶标：LLC-PK1 External Id：CHEMBL2183105

实验名称：Inhibition of human recombinant BACE1 using Glu-Ile-Asp-Leu-Met-Val-Leu-Asp as substr... 来源：ChEMBL 靶标：Beta-secretase 1 External Id：CHEMBL2183110

实验名称：Inhibition of BACE1 in human HEK293 cells expressing APP Swedish mutant assessed as r... 来源：ChEMBL 靶标：Beta-secretase 1 External Id：CHEMBL2183108

实验名称：Inhibition of cathepsin D 来源：ChEMBL 靶标：Cathepsin D External Id：CHEMBL2183109

实验名称：Chemical stability of the compound in 2 N HCl after 18 hrs 来源：ChEMBL 靶标：N/A External Id：CHEMBL2183102

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