N-(Cyclopropylmethyl)-N-(4-(1,1,1-trifluoro-2-hydroxy-4-(4-(methylsulfonyl)phenyl)but-3-yn-2-yl)phenyl)benzenesulfonamide

• 常用名: N-(Cyclopropylmethyl)-N-(4-(1,1,1-trifluoro-2-hydroxy-4-(4-(methylsulfonyl)phenyl)but-3-yn-2-yl)phenyl)benzenesulfonamide
• 英文名: N-(Cyclopropylmethyl)-N-(4-(1,1,1-trifluoro-2-hydroxy-4-(4-(methylsulfonyl)phenyl)but-3-yn-2-yl)phenyl)benzenesulfonamide
• CAS号: 1400887-97-9
• 分子量: 563.6
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₂₄F₃NO₅S₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-(Cyclopropylmethyl)-N-(4-(1,1,1-trifluoro-2-hydroxy-4-(4-(methylsulfonyl)phenyl)but-3-yn-2-yl)phenyl)benzenesulfonamide

物理化学性质

• 分子式: C₂₇H₂₄F₃NO₅S₂
• 分子量: 563.6
• InChIKey: NMMZNDAQGGNURI-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)c1ccc(C#CC(O)(c2ccc(N(CC3CC3)S(=O)(=O)c3ccccc3)cc2)C(F)(F)F)cc1

靶点实验

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实验名称：Volume of distribution at steady state in Sprague-Dawley rat at 0.5 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2071824

实验名称：AUC in Sprague-Dawley rat at 0.5 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2071825

实验名称：Clearance in Sprague-Dawley rat at 0.5 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2071822

实验名称：Mean residence time in Sprague-Dawley rat at 0.5 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2071823

实验名称：Oral bioavailability in Sprague-Dawley rat at 5 mg/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2071828

实验名称：AUC in Sprague-Dawley rat at 5 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2071829

实验名称：Antagonist activity at LXRbeta ligand binding domain expressed in HEK293 cells coexpr... 来源：ChEMBL 靶标：Oxysterols receptor LXR-beta External Id：CHEMBL2071816

实验名称：Metabolic stability in rat liver microsomes assessed as compound remaining at 1 uM af... 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL2071832

实验名称：Displacement of [3H]N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-methy... 来源：ChEMBL 靶标：Oxysterols receptor LXR-beta External Id：CHEMBL2071815

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