N'-(4-(二乙基氨基)-2-羟基亚苄基)异烟酰肼

• 常用名: N'-(4-(二乙基氨基)-2-羟基亚苄基)异烟酰肼
• 英文名: RSVA 405
• CAS号: 140405-36-3
• 分子量: 312.36600
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₂₀N₄O₂
• 熔点: N/A
• 闪点: N/A

用途

RSVA405 is a potent, orally active activator of AMPK, with an EC50 of 1 μM. RSVA405 facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR, and promotes autophagy to increase Aβ degradation. RSVA405 has anti-inflammatory effects through the inhibition of STAT3 function. RSVA405 also can be used for the research of obesity.

名称

• 中文名: N'-(4-(二乙基氨基)-2-羟基亚苄基)异烟酰肼
• 英文名: N'-[1-(4-diethylamino-2-hydroxyphenyl)methylidene]isonicotinohydrazide

物理化学性质

• 分子式: C₁₇H₂₀N₄O₂
• 分子量: 312.36600
• 精确质量: 312.15900
• PSA: 77.82000
• LogP: 2.78820
• InChIKey: GWQPCBPAOAFXSJ-XDHOZWIPSA-N
• SMILES: CCN(CC)c1ccc(C=NNC(=O)c2ccncc2)c(O)c1
• 储存条件: 2-8°C， 干燥

靶点实验

查看更多实验

实验名称：DNDI: Cytotoxicity against human MRC-5 lung fibroblast cells. 来源：ChEMBL 靶标：MRC5 External Id：CHEMBL2095143

实验名称：DNDI: Inhibition of Human African Trypanosomiasis (HAT), STIB 795, in vitro 来源：ChEMBL 靶标：Trypanosoma brucei brucei External Id：CHEMBL2095144

实验名称：Screen for inhibitors of RMI FANCM (MM2) intereaction 来源：11908 靶标：N/A External Id：RMI-FANCM-MM2

实验名称：Growth inhibition of chloroquine-resistant Plasmodium falciparum FcB1 at 1 uM 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL864527

实验名称：HIV Cellular Data 来源：NIAID 靶标：N/A External Id：HIV Cellular Data

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英文别名

• p-(N,N-diethylamino)salicylaldehyde isonicotinoylhydrazone
• N'-[4-(diethylamino)-2-hydroxybenzylidene]isonicotinohydrazide
• Hit2Lead 5113025
• ST 91