6-[4-[2,2-bis(4-fluorophenyl)ethylamino]piperidin-1-yl]-2-N,4-N-bis(prop-2-enyl)-1,3,5-triazine-2,4-diamine

• 常用名: 6-[4-[2,2-bis(4-fluorophenyl)ethylamino]piperidin-1-yl]-2-N,4-N-bis(prop-2-enyl)-1,3,5-triazine-2,4-diamine
• 英文名: 6-[4-[2,2-bis(4-fluorophenyl)ethylamino]piperidin-1-yl]-2-N,4-N-bis(prop-2-enyl)-1,3,5-triazine-2,4-diamine
• CAS号: 140945-01-3
• 分子量: 505.60500
• 密度: 1.23g/cm3
• 沸点: 661.9ºC at 760 mmHg
• 分子式: C₂₈H₃₃F₂N₇
• 熔点: N/A
• 闪点: 354.1ºC

名称

• 英文名: 6-[4-[2,2-bis(4-fluorophenyl)ethylamino]piperidin-1-yl]-2-N,4-N-bis(prop-2-enyl)-1,3,5-triazine-2,4-diamine

物理化学性质

• 密度: 1.23g/cm3
• 沸点: 661.9ºC at 760 mmHg
• 分子式: C₂₈H₃₃F₂N₇
• 分子量: 505.60500
• 闪点: 354.1ºC
• 精确质量: 505.27700
• PSA: 84.46000
• LogP: 4.03580
• InChIKey: GERNFWKTMKWULM-UHFFFAOYSA-N
• SMILES: C=CCNc1nc(NCC=C)nc(N2CCC(NCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)n1
• 蒸汽压: 2.16E-17mmHg at 25°C
• 折射率: 1.612

靶点实验

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实验名称：Ratio of survival time of mice treated with VCR (0.25 mg/kg ip)+modulator given at th... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL732554

实验名称：Increase in adriamycin uptake in modulator-treated cells relative to untreated cells ... 来源：ChEMBL 靶标：DC3F/AD External Id：CHEMBL661956

实验名称：Increase in adriamycin uptake in modulator-treated cells relative to untreated cells ... 来源：ChEMBL 靶标：DC3F/AD External Id：CHEMBL661957

实验名称：Compound was evaluated for in vitro activity in DC-3F/AD cell line (Ratio of IC50(adr... 来源：ChEMBL 靶标：DC3F/AD External Id：CHEMBL661958

实验名称：In vitro activity in DC-3F/AD cell line Ratio of IC50(adriamycin alone) / IC50(adriam... 来源：ChEMBL 靶标：DC3F/AD External Id：CHEMBL662758

实验名称：TP_TRANSPORTER: inhibition of JC-1 uptake (JC-1: ca 0.1 uM, S9788: 5 uM) in K562 and ... 来源：ChEMBL 靶标：ATP-dependent translocase ABCB1 External Id：CHEMBL2076578

实验名称：Percent of cell viability remaining after incubating the cells with the modulator alo... 来源：ChEMBL 靶标：DC3F/AD External Id：CHEMBL662764

实验名称：Percent of cell viability of P388/VCR-20 murine leukemia cells remaining after inocul... 来源：ChEMBL 靶标：P388 External Id：CHEMBL756392

实验名称：Antitumor activity of vincristine against P388 leukemia cell line in mice at a dose o... 来源：ChEMBL 靶标：P388 External Id：CHEMBL758819

实验名称：Antitumor activity of vincristine against P388/VCR leukemia in mice at a dose of 50 m... 来源：ChEMBL 靶标：P388/VCR External Id：CHEMBL758143

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英文别名

• 6-(4-(2,2-di(4-Fluorophenyl)ethylamino)-1-piperidinyl)-N,N'-di-2-propenyl-1,3,5-triazine-2,4-diamine
• 1-[4,6-bis(allylamino)-2-s-triazinyl]-4-[2,2-bis(p.fluorophenyl)ethylamino]piperidine
• S9788
• 1,3,5-Triazine-2,4-diamine,6-(4-((2,2-bis(4-fluorophenyl)ethyl)amino)-1-piperidinyl)-N,N'-di-2-propenyl