N-(3-(4-Methylpiperazin-1-yl)-1-(5-methylpyridin-2-yl)-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

• 常用名: N-(3-(4-Methylpiperazin-1-yl)-1-(5-methylpyridin-2-yl)-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
• 英文名: N-(3-(4-Methylpiperazin-1-yl)-1-(5-methylpyridin-2-yl)-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
• CAS号: 1414973-03-7
• 分子量: 417.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₃N₉O
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-(3-(4-Methylpiperazin-1-yl)-1-(5-methylpyridin-2-yl)-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

物理化学性质

• 分子式: C₂₁H₂₃N₉O
• 分子量: 417.5
• InChIKey: CBGMVWLOYGVWSO-UHFFFAOYSA-N
• SMILES: Cc1ccc(-n2nc(N3CCN(C)CC3)cc2NC(=O)c2cnn3cccnc23)nc1

靶点实验

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实验名称：AUC (0 to 8 hrs) in Sprague-Dawley rat at 10 mg/kg, po administered as cassette dosin... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3588642

实验名称：Antiinflammatory activity in Lewis rat peritonitis model assessed as reduction of TLR... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3588649

实验名称：Antiinflammatory activity in Lewis rat peritonitis model assessed as reduction of TLR... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3588650

实验名称：Antiinflammatory activity in Lewis rat peritonitis model assessed as reduction of TLR... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3588647

实验名称：Antiinflammatory activity in Lewis rat peritonitis model assessed as reduction of TLR... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3588648

实验名称：Activity at rat Pgp assessed as apparent permeability by cell-based assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL3588652

实验名称：Oral bioavailability in Sprague-Dawley rat at 10 mg/kg administered as cassette dosin... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3588657

实验名称：AUC (0 to 8 hrs) in Sprague-Dawley rat at 2 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3588658

实验名称：Antiinflammatory activity in human THP1-XBlue cells assessed as inhibition of TNFalph... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3588655

实验名称：Inhibition of recombinant human IRAK4 at 1 uM relative to control 来源：ChEMBL 靶标：Interleukin-1 receptor-associated kinase 4 External Id：CHEMBL3588656

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